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31.21.1.1.4 Variation 4: Using Nitric Acid on a Solid Support

DOI: 10.1055/sos-SD-031-01277

Aitken, K. M.; Aitken, R. A.Science of Synthesis, (2007311188.

A new development in the 1980s and 1990s was the use of a reagent system consisting of nitric acid on a suitable solid support, which induces selective para nitration of aromatics with ortho/para-directing substituents. The other advantages of solid-supported nitric acid reagents are their mildness in comparison to concentrated nitric acid, and that they can be used as a dispersion in organic solvents. The reactivity of solid-supported nitric acid is comparable to that of concentrated nitric acid.

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References


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