You are using Science Of Synthesis as a Guest.
Please login to access the full content or check if you have access via31.28.1.13.8 Variation 8: Substitution of Arylzincates
Please login to access the full content or check if you have access via
Scholz, U.; Schlummer, B., Science of Synthesis, (2007) 31, 1617.
Arylmagnesium halides are simply converted into the corresponding arylzincates, which themselves may serve as starting materials for a replacement of zinc with amines with the help of a nickel–phosphine catalyst. However, only benzoyloxy-protected amines can be used as the amine reagent, yields are rather low, and the reaction conditions have not yet been developed into a practical procedure. As an example, (4-cyanophenyl)magnesium chloride and 4-(benzoyloxy)morpholine form 4-morpholinobenzonitrile (130) in an acceptable yield (Scheme 139).[225]
Meeeee 888 Meeeeeeee ee 8-Meeeeeeeeeeeeeeeeeeeee eeee (8-Meeeeeeeeee)eeeeeeeee Meeeeeee eee 8-(Meeeeeeeee)eeeeeeeeee[888]
References
| [225] | Meeeee, M. M.; Meeeeee, M. M., Meeeeee, (8888), 8888. |
Return to Top