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Please login or sign up for a free trial to access the full content. Variation 4: Replacement of an Aromatic C—C Bond by a C—N Bond

DOI: 10.1055/sos-SD-031-01728

Scholz, U.; Schlummer, B.Science of Synthesis, (2007311649.

The replacement of a CC bond by a CN bond can be achieved by the well-known Hofmann rearrangement. In a typical example, 2-benzoylbenzamide (197) rearranges to (2-aminophenyl)phenylmethanone (136) in good yield using sodium hydroxide and sodium hypochlorite (Scheme 213).[‌383‌]

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