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DOI: 10.1055/sos-SD-031-01847

Schlummer, B.; Scholz, U.Science of Synthesis, (2007311680.

The most common reaction used to synthesize quaternary ammonium salts is the Menschutkin reaction.[‌20‌,‌21‌] In this method a tertiary amine nucleophile replaces a leaving group in an aliphatic or aromatic nucleophilic substitution reaction. The leaving group thus liberated usually becomes the anion of the ammonium salt (Scheme 2).

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