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32.2.1.1.2.1 Variation 1: Using a Copper(I)/Copper(0) Catalyst

DOI: 10.1055/sos-SD-032-00025

Hashmi, A. S. K.Science of Synthesis, (20083225.

The copper-catalyzed SN2-type substitution of tertiary propargylic alcohols or chlorides (e.g., 6) is one of the methods to give chloroallenes (e.g., 7) (Scheme 3).[‌20‌] Here, the high substitution at one end of the allene is responsible for the clear outcome of the potentially reversible reaction.

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