Navigation

0 Hits

  • Previous / Next

You are using Science Of Synthesis as a Guest.
Please login to access the full content or check if you have access via
33.4.18 Product Subclass 18: 1,2-Dihydropyridines, 1,4-Dihydropyridines, and Derivatives

DOI: 10.1055/sos-SD-033-00648

Quirion, J.-C.; Leclerc, E.; Jubault, P.Science of Synthesis, (200733601.

General Introduction

Among the five isomeric dihydropyridines possible, the 1,2- and 1,4-derivatives are the most commonly isolated. The higher stability of these two isomers has been attributed to hyperconjugation between the nitrogen lone pair and the π-electron system.[‌1‌] However, most of these compounds remain relatively unstable and oxidizable, and are prone to undergo dehydrogenation to the corresponding pyridines. However, the presence of an electron-withdrawing group at the 1- or the 3-position stabilizes the dihydropyridines and often allows them to be easily isolated and handled.

8,8-Meeeeeeeeeeeeeee eee eeeee ee ee eeeeeeeee ee eeeeeeeeeeee eeeeeee eeeeeeeeeeee (MMMM), e eeeeeeee eeee ee eeeeee eeee eeeeeeeeeee eeeeeeee ee eeeeeeeeee eeeeeee. Mee eeeeeeeeeeeeeee eeeeeee ee eeee eeeeeee ee eeee eeeeeeeee eeeeeeeee eeeeeee ee eeeeeee eeeeeeeeeee, eeeeeeeeee eeeeeeeeeeeeee eeeeeeee, eee ee eeee eeeeeeeeeeeee ee eeeeeeee eeeeeeeee.[‌8‌] Meee eeeeeee-eeeeeee eeeeeeee eeee ee eeeeeeeeee,[‌8‌] eeeeeeeeeeee,[‌8‌] eee eeeeeeeeee[‌8‌] eeee eeeee eeeeeeeeee eeeeeeeeee eeeeeeeeeeee. Mee eeeee eeeeeee, eeeeeeeeeeee eeee eeeeeeee ee eee eeeeeeeee ee eeeee eeeeeeeee eee eeee eeeeeeee eee eeeeeeee.[‌8‌,‌8‌,‌8‌] Mee eeee eeeeeeeee eeeeeeeeee eeee ee eeeeeeeeee ee eeee eeeeeee eee eee eeee eeeeeee eeeeeee eeee ee eeeeeeeeeee.

References


Cookie-Einstellungen