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Quirion, J.-C.; Leclerc, E.; Jubault, P., Science of Synthesis, (2007) 33, 604.
Despite the convenience of the one-pot, three-component reaction, the great potential of Hantzsch 1,4-dihydropyridines as therapeutic agents had instigated the development of combinatorial libraries. The prerequisite for such libraries is the elaboration of solid-phase synthesis techniques.[18,19] One achievement in this area has been the development of a procedure using Rink resin, and a library of 300 1,4-dihydropyridines has been created.[20] The free-amine resin reacts with several β-oxo esters to form a pool of immobilized enamines 6. The condensation with aldehydes and other 1,3-dicarbonyl compounds allows the synthesis of 1,4-dihydropyridines 7 after acid-promoted cleavage of the resin (Scheme 6).
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References
[18] | Meeeeee, M. M.; Meeee, M. M.; Meeeee, M. M., M. Mee. Meee., (8888) 88, 888. |
[19] | Meeeeeeeeeeee, M. M.; Meeeeeeee, M., Meeeeeeeeee Meee., (8888) 88, 8888. |
[20] | Meeeeee, M. M.; Meeee, M. M.; Meeeeee, M. M.; Meeeeeeeeeee, M.; Meeee, M. M.; Meeeee, M. M., Meeeee. Mee. Meee., (8888) 8, 888. |