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35.1.1.1.2 Haloalkanes and Halocycloalkanes

DOI: 10.1055/sos-SD-035-00004

Hartung, J.Science of Synthesis, (20073530.

Substitutive chlorination of hydrogen atoms in haloalkanes and cyclohaloalkanes occurs in thermally or photochemically induced reactions with chlorine, chlorine monoxide,[‌41‌] tert-butyl hypochlorite,[‌56‌] dialkyl-N-chloroammonium salts,[‌42‌] or (dichloroiodo)benzene.[‌53‌] Reactivity and selectivity in these reactions are predictable on the basis of guidelines elaborated for aliphatic chlorination (Section 35.1.1.1.1) in combination with effects exerted by substituents other than hydrogen.

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