You are using Science Of Synthesis as a Guest.
Please login to access the full content or check if you have access via35.1.4.1.3 Method 3: Reaction with Chlorine Monoxide
Please login to access the full content or check if you have access via
Pfeiffer, W. D., Science of Synthesis, (2007) 35, 175.
Chlorine monoxide is an efficient ene-type chlorination reagent for alkenes under mild conditions.[16] For example, 4-chloro-1,5-dimethylhex-5-enyl acetate (17) is obtained by dropwise addition of a solution of chlorine monoxide in carbon tetrachloride–diethyl ether to 1,5-dimethylhex-5-enyl acetate (16) at room temperature (Scheme 5). The treatment of the azetidin-2-one derivative 18 with chlorine monoxide in a mixture of carbon tetrachloride–dichloromethane–water affords the corresponding chloride 19 in 85% yield.[16]
Meeeee 8 Meeeeeeeeeee eeee Meeeeeee Meeeeeee[88]
Meeeeeeeeeee Meeeeeeee
8-Meeeee-8,8-eeeeeeeeeee-8-eeee Meeeeee (88); Meeeeee Meeeeeeee:[88]
Me e eeee ee 88 (8.888 e, 8.8 eeee) ee Me8M (8 eM) eee eeeee, eeeeeeee, e eeee ee Me8M (8.888 e, 8.8 eeee) ee MMe8 (8 eM) (MMMMMMM: eeeee) ee ee. Mee eeeeeee eee eeeeeee eee 88 eee eee eeeeee ee ee eeeeeeeeeeee; eeeee: 88 ee (88%).
References
[16] | Meeee, M.; Meeeee, M.; Meee, M.; Meee, M.; Meeeeee, M., Meee. Meee., (8888), 888. |