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35.2.1.5.2.1 Variation 1: Reaction of Alcohols with Aqueous Hydrobromic Acid

DOI: 10.1055/sos-SD-035-00308

Braun, M.Science of Synthesis, (200735326.

The treatment of alcohols with hydrobromic acid provides a simple access to alkyl bromides 6, and the protocol has been applied to primary, secondary, and tertiary alcohols as well as to diols and amino alcohols (Scheme 6). As far as alcohols with a stereogenic hydroxy-bearing carbon atom have been applied, they have been mostly used as racemates (see HoubenWeyl, Vol.5/4, pp374387). However, the reaction of nonracemic alcohols has been described as well, and the stereochemical outcome in these reactions has been investigated.[‌16‌‌18‌]

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References


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