0 Hits

  • Previous / Next

You are using Science Of Synthesis as a Guest.
Please login to access the full content or check if you have access via Method 2: Oxidation of Organosilicon Compounds

DOI: 10.1055/sos-SD-036-00003

Porter, M. J.Science of Synthesis, (20083635.

The oxidation of CSi bonds to afford alcohols is an easy process to carry out provided that an electronegative substituent is also attached to the silicon atom.[‌119‌] The reaction occurs with retention of configuration at the oxidized carbon atom, making it a useful reaction in the asymmetric synthesis of alcohols. The most commonly used methods involve the oxidation of halosilanes, alkoxysilanes, or dimethyl(phenyl)silanes. In the latter case, the first step is the cleavage of the phenyl group from the silicon.