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36.1.1.2.1 Variation 1: Oxidation of Trichlorosilanes

DOI: 10.1055/sos-SD-036-00003

Porter, M. J.Science of Synthesis, (20083635.

Alkyltrichlorosilanes 38 are oxidized to alcohols 39 by hydrogen peroxide in the presence of potassium fluoride and potassium hydrogen carbonate (Scheme 12). The most commonly used solvent system is a mixture of water, methanol, and tetrahydrofuran. As the alkyltrichlorosilanes are generally produced through asymmetric hydrosilylation of alkenes with trichlorosilane, most of the reported examples are secondary alcohols. Thus, this approach provides a two-stage method for the synthesis of optically active secondary alcohols from alkenes. Nevertheless, primary alcohols may also be prepared by this process.[‌120‌]

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