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36.1.2.1.9.2 Variation 2: Reduction of Ozonides

DOI: 10.1055/sos-SD-036-00032

Cox, L. R.Science of Synthesis, (200836118.

Ozonides (1,2,4-trioxolanes) are readily prepared from the action of ozone on alkenes. They can be reduced to alkanols in a variety of ways; thus a transformation involving alkene ozonolysis, followed by reduction of the intermediate ozonide (generally not isolated), provides a very useful two-step unmasking of an alkanol from the corresponding alkene (Scheme 61).

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