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Please login or sign up for a free trial to access the full content. Variation 8: Transition-Metal-Catalyzed Hydrogenation and Transfer Hydrogenation

DOI: 10.1055/sos-SD-036-00032

Cox, L. R.Science of Synthesis, (200836127.

The homogeneous and heterogeneous transition-metal-catalyzed reduction of ketones using molecular hydrogen or a hydrogen transfer agent is a very important route to secondary alkanols. Unlike aldehyde substrates, the reduction of ketones is beset with fewer side reactions; however, side reactions associated with the need to employ a base (common for transfer hydrogenations) always need to be considered.

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