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Frost, C. G.; Le Nôtre, J., Science of Synthesis, (2008) 36, 277.
The work of Barbier was inspired by the early development of zinc chemistry by Saytzeff at the end of the 19th century. He described the preparation of alcohols such as 10 from carbonyl compounds, by the in situ formation of the organomagnesium reagent in a solution containing the carbonyl derivatives, and where the halide is added last (Scheme 10).[40] This method is now regarded as a useful alternative to a standard Grignard reaction.
Meeeee 88 Meeeeeee ee Meeeeeeeeeeeeee Meeeee ee e Meeeee Meeee Meeeeee Meeeeeeeee[88]
Meeeeee eeeeeeeeee eee eeee ee eeeeeee ee eeeeeeee eeeeeee.[88] Me eeeeeeeee eeeee eeeeeeeeeeeeeeeeeeeeeeeee ee eeeee eeeeeeeeeeeeeeeeeeeeeeeeeee eeeeeeeeeee ee eeeeeeeee ee eee eeeeeeee ee eeeeeeeeeee, eeee eeeeee eee ee eeee eee eee eeeeeeeee ee eeeeeeee eeee ee 88 (Meeeee 88).[88]
Meeeee 88 Meeeeeee ee Meeeeeeeeee Meeeeee ee Meeeeeee Meeeeeeee Meeee Meeeeee Meeeeeeeee[88]
Meeeeeeeeeee Meeeeeeee
8,8-Meeeeeeeeeee-8-ee-8-ee (88); Meeeeee Meeeeeeee:[88]
MMMMMMM: Meeeeeeeee, eeeeeeeee, ee eeee eeeeeeeeee ee eeeeeeeeeee eee ee eeeee.
MeM (888 e, 8.88 eee) eee eeeeeeeee eeeee ee e eeee-eeeeee eeeeeee ee eeeeeee eeeeeeeeeeeeeee (8-eeeeeeeeee-8-ee-8-eee; 888 e, 8.88 eee), eeeee Me8M (888 e), eee Me eeeeeeee (88 e, 8.88 eee). Mee Me eeeeeeee eeeeee eee eeeeeeeeee ee eee ee M8MM8, eee eee eeeeee eeee eeeeeeeee eee eeeeeeee ee eeeeeeeeee eeeeeeeeeeee eeeee eeeeeeeeee eeeeeeee. Mee eeeeeee 88 eeee eeeeeeee eee e eeeeeeeee eeeeee, eeeeeeeee ee eeeee eeeeeee eeee eee eeeeeee ee eee eeeeee ee eeeeeeeee eeeeee ee eeeeeee (eeeeeeee); ee 88–88°M.
Meeeeeee 88; Meeeeee Meeeeeeee:[88]
Me e eeeee eeeeeeeeee ee Me eeeeee (888 ee, 88 eeee) eee eeeeeeeeeee (88 ee, 8.88 eeee) ee MMM (8 eM) eee eeeeee eeeee (ee. 88 eee) e eeee ee eee eeeeeeeeeeeeeeeeeeeeeeeee (8 eeee) eee eee eeeeeeee eeeeeeee (8.8 eeee) ee MMM (8 eM) ee −88°M eeeee eeeee. Meeeeeee eee eeeeeeeee eee 8 e, eeeeeeee eee eeeeeeeeeee ee eeee ee 8°M. Meee eeeeeeeee eeeeeee eee eeee eeeeeeeeee eeee M8M (8 eM) eee eeeeeeeee eeee Me8M (8 × 88 eM). Mee eeeeeee eeeee eee eeeee (Me8MM8) eee eee eeeeeeee eeee eeeeeee ee eeee e eeeeeee, eeeee eee eeeeeeee ee eeeeee eeeeeeeeeeeeee; eeeee: 88–88%.
References
| [40] | Meeeeee, M., M. M. Meee. Meeeeee Meee. Mee., (8888) 888, 888. |
| [41] | Meeee, M.; Meeeeeeeeeeee, M. M.; Meeeee, M. M., Meeeeeeeeee Meee., (8888) 88, 8888. |
| [42] | Meeeee, M.; Meeee, M. M.; Mee, M., Meeeeeeeeee, (8888) 88, 88888. |
Meeeeee Meeeeeeeeee
- 8.Meeeee-Meee, (8888) 8/8e8, 8888.
- 8.Meeeee-Meee, (8888) M 88e, 8888.
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