Science of Synthesis

Frost, C. G.; Le Nôtre, J., Science of Synthesis, (2008) 36, 323.

The synthesis of enantiomerically-enriched alcohols by the development of new methods for the asymmetric aryl-transfer reactions to aldehydes is an important area that has been reviewed.[‌338‌] The use of chiral ligands, e.g. ‌106‌–‌111‌, in combination with an appropriate rhodium complex can lead to useful enantioselectivities in the addition of boronic acids to aldehydes (‌Scheme 61‌).

‌Meeeee 88‌ Meeeee Meeeeee Meee ee eee Meeeeeeeeeeeeeee Meeeeee-Meeeeeeee Meeeeeee ee Meeeeee Meeee ee Meeeeeeee[‌888‌,‌888‌–‌888‌]

Mee eeeee eeeeeee ee ee eeeeeeeeee eeeeeee-eeeeeeeee eeeeeeee ee ee eeeeeeeeeee eeee ee ee eeeeeeee eeeeeeee eeeeeeee eee eeeeeeeeeee eeeeee ‌888‌ ee eee eeeeeeeee ee eeeeeee ‌888‌ ee e eeeeee 88% ee (‌Meeeee 88‌).[‌888‌]

‌Meeeee 88‌ Mee Meeeeeeeee Meeeeee-Meeeeeeee Meeeeeee ee e Meeeeee Meee ee ee Meeeeeee[‌888‌]

Meeeee eeeeee eeeeeeeeeee eeee ‌888‌ eee eeee eeee ee e eeeeeeeee eee e eeeeee M-eeeeeeeeeeee eeeeeee eeeeee eeee eeeeeee ee ee 88% ee ee eeeeeee-eeeeeeeee eeeeeeeee ee eeeeeeeeeee eeeee ee eeeeeeee eeeeeeeee.[‌888‌] Meeee eeeeeeee-eeeeeeeeee eeeeeee eeee eeee eeee eeeeeeee, eeeeee eeee eee eeeeeeeeeeeeeeeeee.[‌888‌,‌888‌] M eeeeeeee eeeeee eeeeeeeee ee eee[eeeeee(eeeeeeeeeee)eeeeeee(M)] eee eeeeee ‌888‌ eeeeeeee eeeeeeeeeeeeeee eeee ee ee 88% ee.[‌888‌] Meee ee eee eeeeeee eeeeeeeeeeeeeeeeeeee eeee eeee eeeeeeee ee eee eeeeeee-eeeeeeeee eeeeeeeeee eeeeeeee ee eeeeeeeeeee eeeee ee eeeeeeeee eeeee eeeeee eeeee eeeeeeeeeeeee eeeeee ‌888‌, eeeeeeeee eeeeeeeeeeeeeee ee eeeeeeeee eeeeee eee eeee ee ee 88% ee.[‌888‌]

Meeeeeeeeeee Meeeeeeee

(M)-8-Meeeeeee(eeeeee)eeeeeeee (‌888‌); Meeeeee Meeeeeeee:[‌888‌]

[Me(eeee)(MM8=MM8)8] (8.88 eeee), eeeeee ‌888‌ (8.88 eeee), eeeeeeeeeee-8-eeeeeeeeeeee (8.888 e, 8.8 eeee), eee eeeeeeeee MeM(MM)8 (8.8 eeee) eeee eeeeeeeee ee MMM (8 eM) eee M8M (8 eM) eeeee M8. Mee eeeeeee eee eeee eeeeeee ee 88°M eee 88 e, eeeeeeeeeeee, eee eeeeeeee ee eeeeeeeeeeeeee (eeeeee eee, eeeeee/MeMMe 88:8) ee eeeeee eee eeeeeee eeeeeee; eeeee: 88%; 88% ee.

References