Science of Synthesis

Frost, C. G.; Le Nôtre, J., Science of Synthesis, (2008) 36, 325.

The addition of allylic organometallics to aldehydes is established as a powerful strategy for the synthesis of highly functionalized alcohols.[‌346‌] Crotylboron reagents are believed to react through the chair-like transition states shown in ‌Scheme 64‌. Thus, (E)-but-2-enyl boron reagents afford the anti-homoallylic alcohol ‌115A‌ and (Z)-but-2-enyl boron reagents afford the syn-stereoisomer ‌115B‌.

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References

Meeeeee Meeeeeeeeee

• 8.Meeeee-Meee, (8888) 88/8e, 888.
• 8.Meeeee-Meee, (8888) 88/8e, 888.
• 8.Meeeee-Meee, (8888) M 88e, 8888.