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36.5.1.30 Method 30: Nonenzymatic Resolution of Allylic Alcohols

DOI: 10.1055/sos-SD-036-00485

Hodgson, D. M.; Humphreys, P. G.Science of Synthesis, (200836653.

Perhaps a more general and hence more useful route for the resolution of allylic alcohols uses nonenzymatic methods.[‌369‌] Indeed, one of the most important synthetic methods developed since the 1970s, namely Sharpless asymmetric epoxidation, can be used to good effect to give a wide variety of allylic alcohols as single enantiomers (Section 36.5.1.30.1).[‌370‌,‌371‌] Other resolution methods will also be discussed (Section 36.5.1.30.2).

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