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36.7.2 Product Subclass 2: 1,3-Diols

DOI: 10.1055/sos-SD-036-00589

Nativi, C.; Roelens, S.Science of Synthesis, (200836774.

Many polyketide-derived natural products contain syn- or anti-1,3-diol fragments. Since polyketides constitute a class of compounds among the most biologically active known to date, a great deal of attention has been focused on their stereoselective synthesis. The development of different methods for the stereoselective preparation of 1,3-diols is of paramount importance as, often, even small structural variations result in a lower yield or selectivity than expected according to a known general method. Several reviews are available concerning 1,3 diols and related compounds.[‌88‌‌92‌]