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You are using Science Of Synthesis as a Guest.
Please login or sign up for a free trial to access the full content. Method 2: Synthesis from 1,3-Diols

DOI: 10.1055/sos-SD-037-00246

Griesbeck, A. G.; Sokolova, T.Science of Synthesis, (200837436.

The classical approach for the preparation of cyclic ethers of the oxetane type is the dehydration of 1,3-diols. Nonregioselective methods involve the Brønsted or Lewis acid activated dehydration involving carbenium ion intermediates or concerted displacement reactions. These reactions are applicable only if stereochemical aspects are of no relevance.

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