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37.4.2 Synthesis by Ring-Closing Metathesis

DOI: 10.1055/sos-SD-037-00338

Roberts, S. W.; Rainier, J. D.Science of Synthesis, (200837531.

General Introduction

This contribution provides an overview of contemporary synthetic methods that involve the generation of oxacycloalk-3-enes using ring-closing metathesis (RCM) methodology. Although the use of ring-closing metathesis to generate heterocycles is a relatively recent area of focus, a number of excellent reviews have appeared that are complementary to this contribution in subject and in scope. One review stands out with respect to methodology.[‌1‌] Further reviews describe the use of ring-closing metathesis in total synthesis studies where the generation of heterocycles was critical.[‌2‌,‌3‌] As exemplified by the awarding of the Nobel Prize in Chemistry to Robert Grubbs,[‌4‌] Richard Schrock,[‌5‌] and Yves Chauvin[‌6‌] in 2005, ring-closing metathesis is obviously an important area of synthetic chemistry.

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