Science of Synthesis

Margaretha, P., Science of Synthesis, (2009) 40, 81.

Although O-alkyloximes (oxime ethers) are as easily prepared from carbonyl compounds as are oximes themselves, the indirect reductive sequence of aldehyde/ketone to O-alkyloxime to amine has been used almost exclusively for the asymmetric synthesis of primary amines. The first such results were obtained by boronate or aluminate reduction of oxime ethers bearing a stereogenic center on the O-alkyl group (‌Scheme 27‌, route a), whereas newer research focuses on employing chiral catalysts (‌Scheme 27‌, route b).[‌50‌]

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References

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• 8.Meeeee-Meee, (8888) 88/8, 888.
• 8.Meeeee-Meee, (8888) M 88e8, 888.