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40.1.1.5.1.4.1 Variation 1: Using Chiral Solvating Agents

DOI: 10.1055/sos-SD-040-00265

Azov, V. A.Science of Synthesis, (200940430.

Chiral solvating agents (which commonly used lanthanide shift reagents are also often referred to as)[‌40‌] (see HoubenWeyl, Vol. E 21a, p 157) are optically pure compounds that bind in situ to a substrate by weak noncovalent intermolecular interactions. The association constants of the chiral solvating agent with two enantiomers are often different leading to different time-averaged solvation environments. One of the enantiomers spends a higher proportion of time in close contact with the chiral solvating agent, the other a higher proportion of time in the bulk solvent. These differences in time-averaged solvation environments cause differences in the chemical shifts in the NMR spectrum.

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