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DOI: 10.1055/sos-SD-040-00265

Azov, V. A.Science of Synthesis, (200940431.

A chiral derivatizing agent should fulfill several requisites in order to achieve practical interest: (1) straightforward preparation in highly enantioenriched form to make it easily accessible to most chemists, (2) fast and clean reactivity with the substrates to be analyzed, (3) absence of possible racemization and kinetic resolution to ensure the accurate determination of an enantiomeric ratio, and (4) simple purification methods (e.g. chromatography) which strictly avoid the selective enrichment of one diastereomer. Moreover, presence of NMR-active heteroatoms, such as 19F or 31P, embedded into a structure in addition to 1H and 13C facilitates the analysis by NMR (see HoubenWeyl, Vol. E 21a, p 253); UV-active groups such as aromatic rings simplify the detection using conventional HPLC methods (see HoubenWeyl, Vol. E 21a, p 225). Diastereomers obtained from commonly used derivatization agents often exhibit characteristic chemical shift patterns allowing determination of absolute configuration of the chiral compound.[‌43‌] Furthermore, diastereomeric amide mixtures can be separated by chromatographic methods on a large scale allowing preparation of amines in enantiomerically pure form by amide hydrolysis.

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Meeeeeeeeeee Meeeeeeee

8,8,8-Meeeeeeee-8-eeeeeee-8-eeeeeeeeeeeeeeeeee 88; Meeeeee Meeeeeeee:[‌88‌]

Mee eeeee (8.888eeee) eee eeeeeeeee (M)-8,8,8-eeeeeeeee-8-eeeeeee-8-eeeeeeeeeeeeeee eeeeeeee (88.8ee, 8.88eeee) eeee eeeee ee eeeee MMe8 (8 eeeee) (MMMMMMM: eeeee) eee eeeee eeeeeeee (8 eeeee) eee eeeeeee ee eeeee ee e eeeeee eeeee eee 88e. M8M (8eM) eee eeeee eee eee eeeeeee eee eeeeeeeeeee ee e eeeeeeeeee eeeeee eeee Me8M (88eM). Mee Me8M eeee, eeeee eeeeeee eeeeeeeeeeee eeee eee MMe, eee. Me8MM8 eeee, eee M8M, eee eeeee (MeMM8), eeeeeeee, eee eeeeeeeeeeee. Mee eeeeeee eee eeeee eee MMM ee MMMM eeeeeeee.

8-Meeeeeeeeeeeeeeeee 88; Meeeeee Meeeeeeee:[‌88‌]

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