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40.1.1.5.2 The Mannich Reaction

DOI: 10.1055/sos-SD-040-00275

Ipaktschi, J.; Saidi, M. R.Science of Synthesis, (200940435.

General Introduction

The aminoalkylation of CH-acidic compounds, the Mannich reaction, is a fundamentally important CC bond-forming reaction in organic synthesis. In its classic direct form, the Mannich reaction is an aminoalkylation of aldehydes or ketones that involves a one-pot reaction of three components: (a) a nonenolizable aldehyde, typically formaldehyde, as a source of an electrophile; (b) ammonia or a primary or secondary amine; and (c) an enolizable carbonyl compound as a source of a nucleophile. The products of this three-component reaction are β-amino aldehydes or ketones.

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References