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DOI: 10.1055/sos-SD-040-00275

Ipaktschi, J.; Saidi, M. R.Science of Synthesis, (200940435.

In highly developed organocatalytic Mannich reactions, aldehydes and ketones are treated with in situ generated imines to afford the corresponding Mannich products with good to excellent stereoselectivities. As catalyst, proline and its derivatives occupy a pivotal position due to their ready availability in either enantiomeric form, as well as their ease of handling.[‌17‌]