0 Hits

  • Previous / Next

You are using Science Of Synthesis as a Guest.
Please login to access the full content or check if you have access via Method 4: Synthesis of Compounds Containing Several Quaternary Ammonium Centers

DOI: 10.1055/sos-SD-040-00546

Kruiswijk, E.; Deck, J. A.Science of Synthesis, (200940830.

The synthesis of compounds containing several quaternary ammonium centers from poly­halides and tertiary amines is normally straightforward, although in some cases mixtures of compounds are obtained. For example, the success of reactions that rely upon the N-alkylation of compounds containing two tertiary amino functions may depend on the size and type of the N-substituents as well as the distance between the two nitrogen atoms.