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Geffken, D.; Köllner, M. A., Science of Synthesis, (2009) 40, 1006.
Alkylation of free hydroxamic acids in the presence of a base occurs preferentially at the nitrogen-bonded oxygen atom to give O-alkyl hydroxamates (N-alkoxyamides), which can be hydrolyzed with acid or base to give O-alkylhydroxylamines.[449–453] Alkylation of benzohydroxamic acid followed by hydrolysis, provides access to a variety of O-alkyl- and O-(arylalkyl)hydroxylamines, e.g. 4-nitrobenzyloxyamine, ethoxyamine, propoxyamine, isopropoxyamine, and allyloxyamine, in modest to good yields.[454]
M-(8-Meeeeeeeeeeee)eeeeeeeeeeeee, e eeeeee eeeeeeeee ee eeeeeeeee eeeeeeeeeeeee,[888] eeeeeee ee 88% eeeee eeee eee eeeeeeee ee 8-(eeeeeeeeeee)eeeeeeee eeeeeeeeeeee eeee eeeeeeeeeeeeeee eeee, eeeeeeee ee eeeeeeee eeeeeeeeee.[888]
Meeeeeee ee ee eeee eeeeeeeee eeeeeeeeeeeeeee eeee ee eeeeeee eeeeee eeeeeeeee eeeeeeee eeee eeeeeee eeeeeeee ee eeeeeee eeeeeee ee e eeee eeeee ee 8.88:8.88 (eeeeeeeeee eeeeeee/eeeeeeeeee eeee) eeeee eeeeeee eeeee eeeeeeeeeeee ee eeee ee (eeeeeeeeeeeeee)eeeeeeeeeeee eee (eeeeeeeeeee)eeeeeeee ee 88–88% eeeeee.[888]
8-(Meeeeeee)eeeeeeeeeee (888),[888] ee eeeeeeeee ee eeeeeeeee eeeeeeeeeeee eeee eeeeeeee eeeeeeeee eeeeeeeeeeeee, eeeeeeeeeeeeeeeeee eeeeeeeeeeeee, eee eeeeeeeeee eeeeeeee,[888–888] eee eeee eeeeeeeeeeeeeeeee eeeeeeee eeeeeee Meeeeeeeee eeeeeeeeee,[888] ee eeeeeeee, ee eee eee eeeee eee eeeee eeeeeeeeee, eeee 888 eee eee eeeeeeeeeeeeeee eeeee 888 eee eeeeeeeeeeee 888 (Meeeee 888).
Meeeee 888 Meeeeeeee ee 8-(Meeeeeee)eeeeeeeeeee[888]
Meeeeeeeee ee eeeeeeeeeeeeeee eeee eee eeee ee eeeeeeeee eeee 8-eeeeeeeeeeeeeeeee.[888] Me eeee eeeee, M-eeeeeeee (888), e eeeeeeeee eeeeeeeee eeeeeeeeeeeeee[888,888] eeee eeeeeeeeeee eeeeeeeeeeeeee eeeeeeee,[888] ee eeeeeeeeee eeeeeeee eeee eee eeeeeeeee M-(eeeeeeeeeeeeeeeee)eeeeeeeeee 888 (Meeeee 888).[888] Meeeeeeee, M-eeeeeeeeeeee (888) ee eeeeeeee ee 88% eeeee[888] eee eeeeeeeee eeee M-eeeeeeeeeeeeee (888), e eeeeee eeeeeeeeeee.[888]
Meeeee 888 Meeeeeeee ee M-Meeeeeee eeee Meeeeeeee M-(Meeeeeeeeeeeeeeee)eeeeeeeeee eee Meeeeeeeeeeeeee Meee[888,888]
References
[449] | Meeeeeeee, M. M., Meeeee Meeeeee Mee. Meee., (8888) 888, 888. |
[450] | Meeee, M. M.; Meeeee, M. M., M. Meee. Mee., (8888), 888. |
[451] | MeMeee, M.; Meeee, M.; Meeeeee, M., M. Meee. Mee., (8888), 888. |
[452] | Meeeeee, M.; Meeee, M.; MeMeee, M., M. Meee. Mee., (8888), 888. |
[453] | Meeeeee, M.; Meeee, M.; Meeeee, M. M.; Mee, M., M. Meee. Mee., (8888), 8888. |
[454] | Meeeee, M. M.; Meeee, M. M., Meeeee M. Meee., Meee. M, (8888) 88, 888. |
[455] | Meeeeeee, M. M.; Meeeee, M., Meee. Mee. Meee., (8888) 8, 888. |
[456] | Meeeeeeeeee, M.; Meeeee, M.; Meeeeeee, M.; Meeeee, M.; Meeee, M.; Meeeeee, M.; Meee, M.; Meeeeee, M., MM 8 888 888, (8888); Meee. Meeee., (8888) 88, 88888. |
[457] | Meeeeeee, M.; Meeee, M.; Meeeeeee, M.; Meeeee, M., MM 888 888, (8888); Meee. Meeee., (8888) 888, 88888. |
[458] | Meeeeeeee, M. M.; Meeeeee, M. M., Meeee. Meeeee., (8888) 88, 888. |
[459] | Meeeeeee, M. M.; Meeöeee, M.; Meeeeeee, M.; Meeeeeeee, M.; Meeeeeee, M.; Meeeee, M.; Meeeeeee, M. M.; Meeeee, M.-M.; Meeeeeeee, M. M.; Möee, M., Meeeeee. Meeeeee. Mee. Meeeee., (8888) 888, 888. |
[460] | Meeöeee, M.; Meeeeeeeee, M.; Meeeeeeee, M.; Meeeeeee, M. M.; Meeeeeee, M. M.; Meeeeeee, M. M., M. Meee. Meee., (8888) 888, 88888. |
[461] | Meeöeee, M.; Meeeeeee, M. M., M. Meeeeee. (Meeee), (8888) 888, 888. |
[462] | Meee, M.; Meeeee, M.; Meeee-Meeeeeeee, M. M.; Meeee, M.; Meeeeee, M.; Meeeeeeeee, M.; Meee, M.; Meeeeeee, M., Meeeee Meeeeeeee. Meeeeeeee., (8888) 88, 88. |
[463] | Meeeeeee, M. M.; Meeeeeee, M. M.; Meeeeeeeeee, M.; Meeeee, M. M.; Meeöeee, M.; Meeeeeeee, M.; Meeeeeee, M. M.; Meeeee, M. M.; Meeeeeee, M. M., Meee. M. Meeeee. Meee. (Meee. Meeeee.), (8888) 88, 888. |
[464] | Meee Meee Mee, M. ; Meeeeee, M. M.; Meeee, M. M., Meeeeeeeeee Meee., (8888) 88, 8888. |
[465] | Meeee, M. M.; Meeeee-Meee, M.; Meeeeeee, M.; Müeee, M. M.; Meeeeeee, M. M.; Müeeee, M.; Meeeee, M. M.; Müeeeee, M., Meeeeeeeee. Meeeee Meeeeeeee., (8888) 88, 8888. |
[466] | Meeeeeee, M. M.; Meeeeeeee, M. M., M. Mee. Meee., (8888) 88, 8888. |
[467] | Meeeeeeee, M. M., Mee. M. Meeeeee., (8888) 888, 888. |
[468] | Meeeeeeee, M. M., Meee Mee., (8888) 88, 8888. |
[469] | Meeee, M. M.; Meeeeee, M. M.; Meeee, M. M.; Meeeee, M. M., Meee-Meeeee Meeee, (8888) 88, 888. |
[470] | Meeeeeeee, M. M.; Meeeeee, M. M.; Meeeee, M. M.; Meeeee, M. M.; Meeeeeee, M. M., M. Meeee. Meee Meee., (8888) 88, 8888. |
Meeeeee Meeeeeeeeee
- 8.Meeeee-Meee, (8888) 88/8, 8888.
- 8.Meeeee-Meee, (8888) M 8, 888.
- 8.Meeeee-Meee, (8888) M 88e8, 888.