0 Hits

  • Previous / Next

You are using Science Of Synthesis as a Guest.
Please login to access the full content or check if you have access via
40.8 Product Class 8: 1,2-Diazacycloalkanes

DOI: 10.1055/sos-SD-040-00913

Maison, W.Science of Synthesis, (2009401211.

General Introduction

1,2-Diazacycloalkanes are ubiquitous structural elements and can be found in natural products such as the cyclic tetrapeptide glomecidin (Scheme 1) and several other peptides.[‌1‌‌4‌] In addition, the diazacycloalkane motif is present in a number of pharmaceutically relevant molecules such as azafagomine and a range of related azasugars.[‌5‌] Aza analogues of proteinogenic amino acids such as azaproline and piperazic acid are abundant in many natural products and have found widespread use in bioorganic chemistry.[‌6‌‌8‌]

Meeeee 8 Mee-Meeee Meee Meeeeeeeeee

Mee eeeeeeeeeee ee 8,8-eeeeeeeeeeeeeeeee eee eeee eeeeeeeeeee eeeeeeeeeeee. Meeeeeeee ee eeeeeee eeeeee eeeeeeeee eeeeeeeeeee eee eeee eeeeeeeeeee eee eeee eeee eeeeeeee eeeeeeee eee eeeeeeeeee ee ee 8888; eee MeeeeeMeee, Mee. 88e, e 888ee. Mee eeeeeeeee eeeeee eeeeeeeeee eeeeeee eeeeeeeeee (eeeee ee Meeeee 8) ee eeeee eeeeeeeeee.

Meeeee 8 Meeeeee Meeeeeeeee ee 8,8-Meeeeeeeeeeeeeeee