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40.12 Product Class 12: N-Alkylsulfamic Acids and Derivatives

DOI: 10.1055/sos-SD-040-00990

Sherman, E. S.; Chemler, S. R.Science of Synthesis, (2009401285.

General Introduction

N-Alkylsulfamoyl halides, N-alkylsulfamic acid salts, and N-alkylsulfamides are compounds of growing importance in organic synthesis and medicinal chemistry. For example, certain N-alkylsulfamic acid salts have been used as antipyretics, pressors, and anticoagulants (for example, heparin is an N-alkylsulfamic acid).[‌1‌] Sulfamides are particularly useful as enzyme inhibitors and as nonhydrolyzable components in peptidomimetics (see HoubenWeyl, Vol. E 11, pp 992ff).[‌2‌]

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