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DOI: 10.1055/sos-SD-042-00920

McKenna, C. E.; Kashemirov, B. A.; Błażewska, K. M.Science of Synthesis, (200942811.

Dialkyl hydrogen phosphates represent a very broad class of organophosphorus compounds. They are extremely resistant to hydrolysis, the CO scission having a half-life of about 130000 years at pH 7 and 25°C.[‌86‌] This stability makes the phosphate diester well-suited to linking the nucleosides of DNA to store genetic information. The chemical stability of phosphate diesters relative to the reactivity of triesters is useful in the synthesis of dialkyl/diaryl hydrogen phosphates.

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