Science of Synthesis

McKenna, C. E.; Kashemirov, B. A.; Błażewska, K. M., Science of Synthesis, (2009) 42, 811.

Dialkyl hydrogen phosphates represent a very broad class of organophosphorus compounds. They are extremely resistant to hydrolysis, the C—O scission having a half-life of about 130 000 years at pH 7 and 25°C.[‌86‌] This stability makes the phosphate diester well-suited to linking the nucleosides of DNA to store genetic information. The chemical stability of phosphate diesters relative to the reactivity of triesters is useful in the synthesis of dialkyl/diaryl hydrogen phosphates.

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References

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• 8.Meeeee-Meee, (8888) 88/8, 888.
• 8.Meeeee-Meee, (8888) M 8, 888.