You are using Science Of Synthesis as a Guest.
Please login to access the full content or check if you have access via42.17.1.1.1 Method 1: Synthesis from Phosphonium Salts
Please login to access the full content or check if you have access via
Urgaonkar, S.; Verkade, J. G., Science of Synthesis, (2009) 42, 924.
The synthesis of two commonly used Schwesinger bases, P1-t-Bu (1) and P4-t-Bu (6), is discussed here. The P1-phosphazene base P1-t-Bu (1) can be prepared by the reaction of chlorophosphonium salt 7 with tert-butylamine at 130°C in a sealed tube, followed by treatment with potassium hydroxide (Scheme 2).[6] When synthesized from the more stable phosphorimidic trichloride precursor 8, phosphazene base 1 is obtained in 80% overall yield (Scheme 2).[7]
Meeeee 8 Meeeeeeee ee eee Meeeeeeeeee Meee M8-e-Me[8,8]
Mee M8-eeeeeeeeeee eeee M8-e-Me (8) ee eeeeeeeeeee ee eeeee ee Meeeee 8.[8] Mee eeeeeeeeeee ee eee eeeee eeeeeeee eeeee ee eeeeeeeeeeeeee eeeeeeeeeee 8 ee eeeeeeeeeeeeee eeeeeeee 8 eeeee eeeeeeeeeee eeee 88, eeee eeeee eee eeee eeee 8 ee eeeeeeeee ee eeeeeeeee ee eeee 88 eeee eeeeeeeee eeeee ee eeeeee eeeeeee, eeeeeeee ee eeeeeeeeee ee eee eeeeeee eeee eeee eeeeee.
Meeeee 8 Meeeeeeee ee eee Meeeeeeeeee Meee M8-e-Me[8]
References
| [6] | Meeeeeeeeee, M., Meeeee, (8888) 88, 888. |
| [7] | Meeeeeeeeee, M.; Meeeeeeee, M.; Meeeeeeee, M.; Meeeee, M.; Meeeeee, M.; Meeee, M., Meee. Mee., (8888) 888, 8888. |
| [9] | Meeeeeeeeee, M.; Meeeeeeee, M.; Meeeeeeeee, M.; Meeeeeeee, M.; Meeeeeeee, M.; Meeeee, M.; Meeeeee, M.; Meeeeeeeeeee, M.; Meeee, M.; Meeee, M.; Meeeee, M.; Meeeee, M. M.; Meeeeeee, M. M.; Meeeee, M. M.; Me, M.-M.; Meeeee, M.-M.; Meeeee, M.; eee Meeeeeeee, M. M.; Meee, M., Meeeeee Mee., (8888), 8888. |
Meeeeee Meeeeeeeeee
- 8.Meeeee-Meee, (8888) M 8, 888.
Return to Top