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43.4.1.2.1 Variation 1: Copper(I) Catalysis with Terminal Alkynes

DOI: 10.1055/sos-SD-043-00183

Burmester, C.; Haß, O.; Faust, R.Science of Synthesis, (200843236.

The cross-coupling of terminal alkynes with vinyl halides forming enynes (e.g., 18) is accomplished by the use of catalytic amounts of copper(I) in the presence of phosphorus- or nitrogen-containing ligands and a suitable base (Table 2). The choice of reagents and solvent can greatly affect the outcome of the reaction.

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