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Please login to access the full content or check if you have access via Method 3: Zinc/Palladium-Catalyzed Cross Coupling of Haloarenes and Terminal Alkynes

DOI: 10.1055/sos-SD-043-00304

Griesbeck, A. G.; Soldevilla, A.Science of Synthesis, (200843359.

Another alternative to the classical Sonogashira reaction uses a zinc species, instead of copper(I), as cocatalyst.[‌59‌] A mixture of zinc(II) chloride and sodium iodide forms the cocatalyst, and the reaction affords arylalkynes 28 as shown in Scheme 17. The process is related to both Sonogashira-type reactions and the Negishi coupling, in which zinc acetylides, stoichiometrically formed, are the reagents.

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