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Please login to access the full content or check if you have access via Variation 2: Palladium-Catalyzed Cross Coupling in Water

DOI: 10.1055/sos-SD-043-00304

Griesbeck, A. G.; Soldevilla, A.Science of Synthesis, (200843369.

Cross-coupling reactions without a copper cocatalyst may be carried out under aerobic conditions; in the absence of copper, the copper-mediated oxidative homocoupling, which is a problem in traditional Sonogashira couplings, is no longer an issue (see examples mentioned in Section[‌88‌] Moreover, water can be used as an environmentally friendly solvent. Copper-mediated Sonogashira reactions in water are discussed in Section, and aqueous reactions in the absence of a copper(I) cocatalyst are discussed here. As in a previous example,[‌75‌] the coupling of peptidic molecules, forming an arylalkyne motif, is possible,[‌93‌] using a trisulfonated phosphine ligand and a palladium(0) source.

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