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44.2.1.6.7 Variation 7: Carbonylation Reactions

DOI: 10.1055/sos-SD-044-00109

Ohno, H.; Tomioka, K.Science of Synthesis, (200844134.

Carbonylation of allenylpalladium species is an extremely useful technique for the synthesis of allenic esters and their derivatives. Carbonylation of propargylic carbonates 324 in the presence of a palladium(0) catalyst and an alcohol such as methanol, propan-2-ol, butan-1-ol, or tert-butyl alcohol gives allenic esters 325 (Scheme 109).[‌175‌] Propargylic halides also undergo alkoxy- or amidocarbonylation on treatment with methanol or diethylamine in the presence of a palladium catalyst and carbon monoxide (2MPa).[‌176‌]

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References


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