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45.4.2.1.1.1 Variation 1: Lewis Acid Catalyzed Friedel–Crafts Alkylation of Arenes with Alkyl Halides

DOI: 10.1055/sos-SD-045-00097

Zysman-Colman, E.Science of Synthesis, (201045159.

Throughout the 140-year history of FriedelCrafts alkylation chemistry, two Lewis acid catalysts have become preeminent (Scheme 2). Despite its limited solubility in apolar solvents, anhydrous aluminum trichloride, first introduced by Friedel and Crafts, remains a first-choice catalyst. Boron trifluoride and related complexes have also had widespread appeal since the 1920s.

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References