Science of Synthesis

Gandon, V.; Thorimbert, S.; Malacria, M., Science of Synthesis, (2009) 46, 210.

The titanium-mediated syntheses of E,E-exocyclic dienes from substituted diynes ‌134‌ may be easily performed in the presence of titanium(II) alkoxides or cyclopentadienyltitanium derivatives. These reactions allow the preparation of five-, six-, or seven-membered carbo- or heterocycles.[‌117‌,‌118‌] For example, the intermediate titanacyclopentadienes ‌135‌ can be trapped with aldehydes, and the adducts then hydrolyzed to give highly functionalized dienes ‌136‌ (‌Scheme 45‌).[‌119‌]

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References