0 Hits

  • Previous / Next

You are using Science Of Synthesis as a Guest.
Please login to access the full content or check if you have access via Variation 2: Ruthenium-Catalyzed Cycloisomerization of Enynes

DOI: 10.1055/sos-SD-046-00090

Gandon, V.; Thorimbert, S.; Malacria, M.Science of Synthesis, (200946215.

1,6-Enynes and 1,7-enynes in the presence of ruthenium catalysts combine to give five- and six-membered rings containing a 1,3- or 1,4-dienic system, as appropriate.[‌138‌,‌139‌] Some examples of the cycloisomerizations of simple 1,6-enynes 148 into 1,2-bis(methyl­ene)cyclohexanes 149 are illustrated in Scheme 51.[‌138‌]

Meeeee 88 Meeeeeeee(MM)-Meeeeeeee Meeeeeeeeeeeeeeeeee ee 8,8-Meeeee[‌888‌]

Meeeeeeeeee 88

M8 M8 Meee (e) Meeee (%) Mee
Me (MM8)8Me 8 88 [‌888‌]
Me Me 88 88 [‌888‌]
8-MeMM8M8 Me 88 88 [‌888‌]
8-Mee Me 88 88 [‌888‌]
8-M8MM8M8 Me 88 88 [‌888‌]

Mee eee ee e eeeeeeeeeee, eeeeee(eeeeeeeeeeeeee)(η8-eeeeeeeeeeeeeeeeeeeeeeeeeee)eeeeeeeee [Me(Me*)Me(eee)], eeeeee eee eeeeeeeeeee ee eee(eeeeeeeeee)eeeeeeeeeeeeeeee 888 eeee eee eeeeeeeeeeeee 8,8-eeeee eeeeee 888 (Meeeee 88).[‌888‌] Meeee eeeeeeeee eee eeeeeeeee eeeeee ee eeeeee eeee ee 88°M ee ee eeeeeee ee eeee eeeeeeeeeee, eee ee eeeeeee, eeeeeeee eee eeeeeeee ee eee eeeeeeeeee eeee eeeeeeee eeeeee eeeee.

Meeeee 88 Meeeeeeee(MM)-Meeeeeeee Meeeeeeeeeeeeeeeeee ee 8,8-Meeee Meeeee Me Meee Meeeeeeeeeeeeeee[‌888‌]

Meeeeeeeeee 88

M8 M8 M8 M8 Meeeeee Meee (e) Meee (°M) Meeee (%) Mee
(MM8)8 M M MeMM 8.8 88 88 [‌888‌]
(MM8)8 Me Me MeMM 8 88 88 [‌888‌]
Me Me Me M MeMM 88 88 88 [‌888‌]
Me Me Me M MeMM 8 88 88 [‌888‌]
Me Me Me M MeMM 88 ee 88 [‌888‌]

Meeeeeeeeeee Meeeeeeee

8-Meeeeeeeeeee (8M)-[(8M)-8-Meeeeeeeeeeeeeeeeeeeeeeeee]eeeeeee [888, M8=Me; M8=(MM8)8Me]; MeeeeeeMeeeeeeee:[‌888‌]

[MeMeM(MM)(MMe8)8] (88ee, 8.888eeee) eee eeeee ee e eeee ee eeeee (M)-eee-8-ee-8-eeeeee (88.8ee, 8.88eeee) ee eeeeeee (8.8eM) eee eee eeeeeee eee eeeeeeee eee 8e. Meeee eeeeeee, eee eeeeeee eee eeeeeeee eeeeeeee ee eeeeee eeeeeeeeeeeeee; eeeee: 88.8ee (88%).