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46.5.3.2.2 Variation 2: Ruthenium-Catalyzed Cycloisomerization of Enynes

DOI: 10.1055/sos-SD-046-00090

Gandon, V.; Thorimbert, S.; Malacria, M.Science of Synthesis, (200946215.

1,6-Enynes and 1,7-enynes in the presence of ruthenium catalysts combine to give five- and six-membered rings containing a 1,3- or 1,4-dienic system, as appropriate.[‌138‌,‌139‌] Some examples of the cycloisomerizations of simple 1,6-enynes 148 into 1,2-bis(methyl­ene)cyclohexanes 149 are illustrated in Scheme 51.[‌138‌]

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M8 M8 M8 M8 Meeeeee Meee (e) Meee (°M) Meeee (%) Mee
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References


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