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Please login to access the full content or check if you have access via Variation 4: Iridium-Catalyzed Cycloisomerization To Give Vinylcycloalkenes

DOI: 10.1055/sos-SD-046-00090

Gandon, V.; Thorimbert, S.; Malacria, M.Science of Synthesis, (200946223.

Reactions promoted by iridium(I) complexes are less commonly used than those that employ platinum or gold catalysts. However, certain iridium complexes do catalyze the cycloisomerization of 1,6-enynes provided these substrates lack a substituent at the terminus of the triple bond.[‌140‌,‌176‌] Such a starting material is the diester 176, which is transformed into the cyclopentene 177 in almost quantitative yield using a carbonyliridium complex as the catalyst (Scheme 62).[‌140‌]

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