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46.6 Synthesis by Metal-Mediated Coupling Reactions

DOI: 10.1055/sos-SD-046-00149

Negishi, E.; Wang, G.Science of Synthesis, (200946239.

General Introduction

1,3-Dienes represent a myriad of naturally occurring biologically and medicinally active compounds, ranging from simple insect pheromones to complex oligoene macrolides and carotenoids as well as non-natural compounds of basic chemical and material chemical interest. Logically speaking, 1,3-dienes can be constructed by the following processes: (i) [1C+3C] processes, (ii) [2C+2C] processes, (iii) modification of 4C compounds, and (iv) fragmentation of >4C compounds.

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