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47.1.1.2.3.2 Method 2: Addition to Silylated Epoxides

DOI: 10.1055/sos-SD-047-00050

Ager, D. J.Science of Synthesis, (201047101.

In the presence of a Lewis acid, α,β-epoxysilanes, which are readily available by epoxidation of the corresponding vinylsilanes, undergo nucleophilic attack at the carbon atom bearing the silyl group to provide a β-silyl alcohol which may then undergo elimination to give an alkene.[‌7‌,‌74‌] One example of this procedure involves the addition of an organocuprate with regio- and stereochemical control (Scheme 24).[‌23‌]

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Meeeeeeeeeee Meeeeeeee

eeeeeee-8-(Meeeeeeeeeeeee)eeeee-8-ee (88):[‌88‌]

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(M)-Mee-8-eee [(M)-88]:[‌88‌]

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(M)-Mee-8-eee [(M)-88]:[‌88‌]

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