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47.1.4.5.4 Variation 4: Cope Elimination from N-Oxides

DOI: 10.1055/sos-SD-047-00322

Kostikov, R. R.; Khlebnikov, A. F.; Sokolov, V. V.Science of Synthesis, (201047821.

The pyrolysis of amine oxides constitutes a reliable synthesis of unrearranged alkenes. Its importance in this regard, however, has largely been reduced by the development of the Wittig alkenation reaction. Nevertheless, this so-called Cope elimination still plays a role in the degradation of naturally occurring nitrogen-containing compounds (see also HoubenWeyl, Vol. 5/1b, pp 238249).[‌181‌]

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