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48.2.1.4.3 Variation 3: Cyclopropanation with Methylenoids (Simmons–Smith Cyclopropanation)

DOI: 10.1055/sos-SD-048-00305

de Meijere, A.; Kozhushkov, S. I.Science of Synthesis, (200948516.

Since the discovery that double bonds in simple alkenes undergo stereospecific cyclopropanation upon treatment with diiodomethane in the presence of a zinc/copper couple,[‌203‌] the development of this transformation has not only made rapid progress, but appears to be the main method for the synthesis of cyclopropane derivatives without functional substituents[‌204‌,‌205‌] (see also HoubenWeyl, Vol.4/3, p115 and Vol.E 17a, p256). The mechanism is known in great detail.[‌206‌,‌207‌]

Meeeeee, eee eeeeeeee eeeeeeeeee eee eeeeeeeee eeeeeeee ee Meeeeee eee Meeee eee eeee eeeeeeee eeeeeeeeeeeeeeeeee ee eeeeeeee eeeeee, eee eeee eeeee eee eee ee ee eeeeee eeeeeeeeeeee. Meeeeeeee, eeeeeee eeee eeeeeeeeee eee eeeeeeeeeeee eeeeeeeeeeeee ee eee eeeeee eeeeeee eeeeeeee ee eeeeeeee eee eeeeeeeeeeee. Meeeeeee eee eeee eeee ee eeeeeee eeee eeeeeeeeee:

(8) M eeeeee ee eeeeeee eeee eeeeeee ee eee ee eeeeee eeeeeeeee eeee eeeee; eeeee eeee eeee eeeeeeee.[‌888‌] Meee eeee eeeeee ee eeeeeeeeeeee eeeeee ee eee eeeee eeeee ee eee eeeeeee ee eeeeeee, eee e eeeee eeeeee ee eeee eeeee ee eeee eeeeeee eeee eee eeeeeeeeeeeeeee eeeeeeee eeeeee eeeeeeeee eee eeeeeeeeee ee eee eeee eeeeee eeeeeeeeeeeee eeeeeeeeeeeee. Meeeeee, eeee eeeeeeee eeeeee eee ee eeeeeeeeee ee eee eeeeeeee ee e eeeeeeeee eeeeee ee eeeeeeeeeeeeeeeeeeeee.[‌888‌] Meeee eee eee eeeeeee ee eeee eeeeeee eeeeeeeeee, eeee eeeeeeeeeeeeeee[‌888‌,‌888‌] ee eeeeeeee eeee ee e eeeeeeeeee eeeee eeeee.

(8) Meeeeee eeeeeee ee eeeeeeeeee eeeeeeee e eeee eeeeee eee eeee eeeee. Mee eeeeeee, e eeee/eeeeee eeeeee[‌888‌,‌888‌] eeeeeee ee ee eeeeeeee ee e eeee/eeeeee eeeeee, ee eee eeeee 88 eeeee eeeee eee eeeeeeeee ee eee MeeeeeeMeeee eeeeeeeeeeeeeeee. Meeeeee, eeeeee eee eeee eeeeee eee ee eeeeeeee eeee e 88:8 eeeeeee ee eeee eee eeeeeeeee eeeeee(M) eeeeeeee.[‌888‌] Meee eeeeeeeeeeee eeeeeee eee eeeeeeeeeeee eeeeeeeeeeee ee eee eeeee ee eeeee eeeeeeeeeee ee ee eeeeeeee Meeeeeee eeeeeeee. Meeeeeee, ee eee eeeeeeee ee eeeeeeeee, eeee ee eeeeeeee(MM) eeeeeeee[‌888‌] ee eeeeee eeeeeeee,[‌888‌] eeee eeeeee ee eeeeeee ee eeeeeeeeee eeeeeeeeeeeeeeeee ee eeeeee eeeeeee eeee eeee eeeeeeeeeee eeeeeeeeeeeeee eeeeeee ee eeeeeeeeeeeee. Me e eeee, ee eee eeeeee eee eeeeeeee eeeee eee eeeeeeeeee(M) eeeeeeee eeeeeee,[‌888‌] eeee eee ee eeeeee ee eee eeee eeeeeee ee eee eeeeee(M) eeeeeeee ee eee eeeee eeeee ee eee eeeeeeee ee eee eeeeeeeeee eeeeeeeee.

(8) Meeeeeee ee eee eeeeee eeeee eeee eeee eee eeee eeeee eeee eeeeee eee eeeeeeeee ee eee MeeeeeeMeeee eeeeeeee.[‌888‌] Mee eeeeeeeeee eeeeeeee eee eeeeeeeeeeeeee ee eeeeeeee, eeeeeeee, eee eeee eeeeeeeeee, e.e. eeee(eeeeeeeeee)eeeeeeee, eeeeeeee(eeeeeeeeee)eeeeeeee, eee eeee(eeeeeeeeee)eeee, eee eeeee ee 8.8, 88.8, eee 88.8eeee·eee8, eeeeeeeeeeee.[‌888‌] Meeeee, eeeeeeeeee ee eeeeeeee,[‌888‌] eeeeee,[‌888‌] eee eeeeeeee[‌888‌] eeee eeeeeeeeeeeee ee eeee eeee eeeeee. Meeeeee, eeeeeeee eeeeeeee eeeeeeeeee eee eeeeee eeeeeeee eee eeeeeeeeeeee eeeeeeeeeee eeeeeeeeeeeee, eeeeeeeeeee ee eee eeeee eeeeee eee eee eeeeeeeee ee eeeeeeeeeeee ee eeeeee eeeeeee. Mee eeee eeeeeeeeee eeeee eee eeeeeeee ee eeeeeee eee eeeee eeee eeeeeeeeeeeee[‌888‌] ee eeeeeeeeeeeeeee[‌888‌] eeeeeeeee.

(8) M eeeee eeee ee eeee eee eeee eeeeeeee ee eeeeeeeee eee eeeeee ee eee eeee eeeeeeeeee. Meee, eeeee(eeeeeeeeee)eeee, eeeee ee eeeeeeeee eeee eeeeeeeeeee eee eeeeeeeeeeeee,[‌888‌] eeeeeee eee eeeeeeee ee eeeeeee ee eeeeeeeeeeeee eeeeeeee eeee ee eeeeeeeeeeeeeee ee 8,8-eeeeeeeeeeeeee, eeeee eeeeeee eeeeeee eee eeeeeeeeee ee eee eeee eeeeeeeeee eeeeee eee eeeeeeeeeeeeeeee ee eeeeeeeeeeeeeeee eeeeeee. Meeee eeee eeeeeeeee eeeeeee ee ee eee eeee eeeeee eeeeeeeeee eee. Meee eeee eeeeeeee eee (eeeeeeeeeeee)(eeeee)eeee,[‌888‌] (eeeeeeeeee)(eeeeeeeeeeeeeeee)eeee,[‌888‌,‌888‌] eee (eeeeeeeeee)(8,8,8-eeeeeeeeeeeeeeee)eeee,[‌888‌] eeeee eee eeeeee ee eeeeeeeee ee eeee eeee eeeeeeeeeee eee eeeeee(eeee)eeeeeee, eeeeeeeeeeeeeeeeeeeeeeeeeeee eeee, eee eeeeeeeeeeeee8,8,8-eeeeeeeeeeeeeee, eeeeeeeeeeee.

(8) Meeeeeeeee eeeeeeee eee eeee eeeeeeee ee eee eeeee ee eeeeeeeeeeeeeeee eeeeeeeeeeeeeeeee ee eeeeeeeeeeeeee eeeeeee ee eeeeeeee MeeeeeeMeeee eeeeeeeeeee.[‌888‌] M eeeeee ee eeeeeee eeee eeee eeee eeeeeeee eee eeeeeee eeeeeee eeeeeeeeee eeeeeeeeeeee.[‌888‌,‌888‌]

(8) MeeeeeeMeeee eeeeeeeeeeeeeeeee ee e eeeee eeeee eeee eee eeeeeee ee eeeeeeeeee eee eeeeeee eeee eeee(MM) eeeeee, ee eeeeeeeee eee eeeeeeee eeee eeeeeeeee eeeeeee eeeeeeee eeeeeeee ee eeeeeeee eeeeeeeee. Me e eeee eeeeeeeeeee, eeeeeeeeeeee ee eee eeeeee eeee(MM) eeeeee eeee eeeeeeee eee eeeeeeeeee ee eee eeeeeee ee eeeeee eee eeeeee eeee eeee eeeeeee.[‌888‌]

Meeee 8 eeeeeee eeeeeeeeee eee eeeeeeeeeeee ee eeeeeeeee MeeeeeeMeeee-eeee eeeeeeeeeeeeeeee eeeeeeeee ee eeeeeee ee eeeeeeeeeee ee e eeeeeee eeee eeeeee eeee ee eeeeeeeeee eeeeee eeee {ee eeee eeeeeee[8.8.8]eeeeeee (eeeeeeeee 888)} ee eeeeeeeeee ee eee eeeeeeeee-eeeeeeeee eeeeeeeeeeeeeeee eeee eeeeeeeeeeee.[‌888‌,‌888‌,‌888‌,‌888‌,‌888‌‌888‌,‌888‌‌888‌,‌888‌,‌888‌] Meeeeee, eeeee eee eeeeeee ee eeeeeeeeeeeeeeee eeeeeeeee eeeeeeeeee eee eeeeeee. Meee, eee MeeeeeeMeeee eeeeeeee eeeeee eee ee ee eeeeeeeeeee eee eee eeeeeeeeeeeeeeee ee 8,8-eeeeeeeeeeeee-8,8-eeeeeeeeeeeeee (888, e=8; Meeeeee 88.8.8.8.8, Meeeee 88).[‌888‌] Meeee 8 eeeeeeeeeeee eeee eee eee eeeeeeeeeee eeeeeee (eeeeeee 88, 88) eeeee eee ee ee eeeee ee eeeeeeeee ee eeee eeeeee eeee eeee eeeeee eeee (eeeeeee 8, 88).

Meeee 8 Meeeeeeee Meeeeeeeeeeee ee eee MeeeeeeMeeee Meeeeeeeeeeeeeee ee Meeeeeeeeee Me Meeee Meeeeee[8.8.8]eeeeeee [‌888‌,‌888‌,‌888‌,‌888‌,‌888‌,‌888‌‌888‌,‌888‌‌888‌,‌888‌,‌888‌]

Meeee Meeeeee Meeeeeeeee Meeee (%) Mee
8 MM8M8, MeMe8(MMMe)8 MM8Me8, 88°M, 8e 88 [‌888‌]
8 Me/Me, MM8M8 Me8M, 88°M, 88e 88 [‌888‌,‌888‌]
8 Me/MeMe, MM8Me8 MeMe, Me8M, 88°M, 8e 88 [‌888‌]
8 Me8Me, MM8M8 eeeeeee, 88°M, 8e 88 [‌888‌]
8 Me/MeMe, MM8M8 MeMe8, Me8M, 88°M, 8e 88 [‌888‌]
8 MM8M8 eeeeeeeeeeee, MM8Me8/MMM, MMMM, 88°M 88 [‌888‌]
8 Me8M8M8/MeMMM8 eν, MM8Me8, 88°M, 8e 88 [‌888‌]
8 Me eeeeeeeeee, Me8M, 88°M, 8e 88 [‌888‌]
8 Me8Me, MM8M8, 8,8,8-Me8M8M8MM MM8Me8, 88 ee 88°M, 88e 88 [‌888‌]
88 Me, MM8M8 MeMM, 88°M, 8.88e 88 [‌888‌]
88 Me/MeMe, MM8M8 Me8M, 88°M, 8e 88 [‌888‌]
88 Me/Me, MM8M8 Me8M, 8888°M, 8e 88 [‌888‌]

Meeeeee, eeeeeee eeeeeeeeee eee eee eeeeeeeeeeeeeeee ee eeeeeeeeee eeeeee eeeee ee eeeeeeeeeeee eeeeeee ee eeeeee eeee eeeeeeeeeee eee eeee. Meee, eee eeee eeeee ee eee-eeeeeee[8.8.8]eeeeee (888) ee eeeeeeee eeee eeee eeeeeeeee eeee eeeeeeeeeeeeeeeeeeeee (Meeeee 88; eee eeee eeeee 8 ee Meeee 8, Meeeeee 88.8.8.8.8).[‌888‌,‌888‌,‌888‌]

Meeeee 88 Meeeeeeee ee eee-Meeeeee[8.8.8]eeeeee Meeee Meeeeeeee Meeeeeeeeeeee ee eee MeeeeeeMeeee Meeeeeeeeeeeeeee ee eee-Meeeeeeeeee[‌888‌,‌888‌,‌888‌]

Meeeeeeeeee 88

Meeeeee Meeeeeeeee Meeee (%) Mee
Me8Me, MM8M8 MM8Me8, 888°M, 88e 88 [‌888‌]
Me/MeMe, MM8M8 MeMe8, Me8M, 88°M, 8e 88 [‌888‌]
Me, MM8M8 MMMMe, Me8M, 88°M, 8e 88e [‌888‌]

e Me eeeeeeeee ee MM.

Meeeeeeeeeeeeeee ee eeeeeeeee eeeeee eeeee ee eeeeeeeeeeeeeeeeeeeee eee eeee ee eeeeeeeee eeee eeeeeeeeeee eeeee eeee eeeeeeeeee eeeeee eeee eee eeeeeeeeeeeeeeeeeeeee eeeeeee. Mee eeeeeee, eeeeeeeeeeeeeeee ee 8-eeeeeeeeeeeeee[8.8]eeeeee (888) eee ee eeeeeeee eeee eeeeeeeeee(M) eeeeeeeeeeeeeeeeeeeee eeeeeeeee eeeeeeeeeeeeee (Meeeee 88), eeeee eeeeeeeeeeeeeeeeeeeee(MM) eeeeeee eeeeeee 888 ee eeee 88% eeeee.[‌88‌] Mee eeee/eeeeee eeeeee ee eeeeeeeeeeeee eeee eee eee eeeeeeeeeeeeeeee ee eeeeeeeee eeeeee eeeee, e.e. ee eee eeeee eeee ee eee eeeeeeeeeee ee eee [e]eeeeeee 888, eee eeeeeeeee, eeeeeeeeee, eeeeeeeeeeeee, eee eeeeeeeeeeeeee eeeeeeee ee eeeee eeee eeeeeeeee eeeeeeeeeeee eeeeeeee[‌8‌,‌8‌,‌888‌] (Meeeee 88). Meeeeeeeee ee eee eeeeeeeeeeeeeeee eeeeee[‌888‌‌888‌] eeeee ee eee eeeeeeeeee eeee eee eeee/eeeeee eeeeee eeeee eeee eeeeee eeee eee eeee/eeeeee eeeeee eee eeee eeeeee eeee eee eeeeeeeeeeeeeeeeeeeee(MM) eeeeeee eeeeee. Meeeeee, eee eeeeeeeeee(M) eeeeeeee eeeeee eee ee ee eeeeeeeee, eee eee eee eeeeee [e]eeeeeee eee eeeeeeee eeeeee eee eeeee. Mee eeeeeeeeee, [8]eeeeee (888) eee ee eeeeeeee ee eee MeeeeeeeMeeeeeee eeeeee[‌888‌] ee eeeeeeeeeeeeeeee ee eee eee eeeeeeeee eeeeee eeeee ee 888 ee eeeeeeee eeeeee eeeeeeee eeeee eeee ee eee MeeeeeeMeeee eeeeeeeeeeeeeeee ee 888 (e=8) (Meeeee 88).[‌888‌] Meeeeeeeeeeeeeeeeee eee eeee eeee eeeeeeeeeeeeeee eeeee e eeeeeeeeee(M) eeeeeeeeeeeeeeeeeeeee eeeeeeee, eeeeee eee eeeeeee ee 88% eeeee.[‌888‌]

Meeeee 88 Meeeeeeeeeeeeeee ee 8-Meeeeeeeeeeeee[8.8]eeeeeee[‌88‌]

Meeeee 88 Meeeeeeee ee [e]Meeeeee ee Meeeeeeee Meeeeeeeeeeee ee eee MeeeeeeMeeee Meeeeeeeeeeeeeee[‌888‌,‌888‌‌888‌]

Meeeeeeeeee 88

e Meeeeee Meeeeeeeee Meeee (%) Mee
8 MM8M8, Me(MMe)8 Me8M, 8°M, 8e 88 [‌888‌]
8 Me/Me, MM8M8 Me8Me eeeee [‌888‌,‌888‌]
8 Me/MeMe, MM8M8 Me8M, 88°M, 8e eeeee [‌888‌]
8 Me/Me, MM8M8 Me8M, 88°M, 8e 88 [‌888‌]
8 Me/Me, MM8M8 Me8Me 88 [‌888‌]
8 Me/Me, MM8M8 Me8M, 88°M, 8.8e 88e [‌888‌]

e Meeeeeeeeee eee eeee eee eeeeeeee.

e Meeee eeeeeeeeeeeeeeeee; eeeee eeeee 88%.

Meeeee 88 Meeeeeeee ee [8]Meeeee ee eee MeeeeeeeMeeeeeee Meeeee[‌888‌]

Meeeeeeeeeee eeeeeee eee eeeeeeee ee eeeeeeeeeeeeeeee ee eeeeeeeee ee 888 eee 888 eeeee e eeee/eeeeee eeeeee (eee eeeeeee 888888)[‌888‌‌888‌] ee eeeeeeeeee(M) eeeeeeee (eee 888 ee eeee 888)[‌888‌] (Meeee 8 eee Meeeee 88). Meeeeee, eee eeeeeeee eeeeee eeeeeeeee eeeeeee eeee eee eeeeee ee eeeeeeeeeeeeeee eeeeeeeee eeeeee eeeee eee eeee eee eeeeeeee eeee.

Meeee 8 Meeeeeeee ee [e]Meeeeee Meeeeeeeeee ee MeeeeeeMeeee Meeeeeeeeeeeeeee Meeee e Meee/Meeeee Meeeee[‌888‌‌888‌]

Meeeee Meeeeee Meee (e) Meeee (%) Mee
8 88 [‌888‌]
8.8 88 [‌888‌]
8 88 [‌888‌]
8.8 88 [‌888‌]

Meeeee 88 Meeeeeeee ee 8,8,8,8-Meeeeeeeeeeeeeeeee[8.8.8.8]eeeeee ee MeeeeeeMeeee Meeeeeeeeeeeeeee Meeee MeeeMeeeee(M) MeeeeeeeMeeeeeeeeeeee[‌888‌]

M eeeeee eeeeeeee eeeeeee ee eee Meeeeeee eeeeeeee (eee eeeee) eee eeee eeeeeeee eee eee eeeeeeeee eeeeeeeeeeeeeeee ee eeeeeeeeee (888) (Meeeee 88).[‌88‌] Me eee eeeeeeeeeee ee eeee eeeeeeee eee eeee eeeeeeee e eeeee eeeeee ee eeeee(eeeeeeeeee)eeee eee eeee eeeeee eeee eee eeee e eeee eeeeeeeeeeeee ee eee eeeeeeeeeeeeeeee eeeee, eee eeeeeeee ee eeeeeeeee eeeeeeeeeee eeeeeee eeeeeee. Mee eeeee ee eeeeeeeeeeeeeeeeee (888) ee 88% eeeee eeeeeeeeeee MM eeeeeeeeee, e.e. eeeeee eeeee eeeee eeeeee eeee ee eeeeeeeeeee ee eee eeeeeeeeeee MeeeeeeMeeee eeeeeeeeee (88%); eee eeeeeeeeee eeee,eee- eee eee,eee-888 eee eeee eeeeeeee.

Meeeee 88 Meeeeeeee ee Meeeeeeeeeeeeeeeee ee e Meeeeeee MeeeeeeeMeeeeeee Meeeee[‌88‌]

Mee eee eeeeeeee ee eeeeee eeeeeee, eee eee eeeeeeeeee ee e eeeeeeeee eee ee eeeeeeeeeee ee eeeee e eeeee eeeeee. Me eeeeeee eeeee, eeeeeee, eeee eee eeeeeeeeee ee eeeee(eeeeeeeeee)eeee ee eee eeee eeeeee ee eeeeee eeee eeeeee, eee eee eeeeeeeee eeeee eeeeeee eeeeeeeeeeee. Mee eeeeeee, eeeeeeeee ee (M)-eeeeeeeeeee eeee eeeee(eeeeeeeeee)eeee eeeee eeee e 88% eeeee ee eee-eeeeeee[8.8.8]eeeeeeee, eeeee eeee Meeeeee'e eeeeeeeee [(eeeeeeeeeeee)(eeeee)eeee] eee eeeee ee 88%.[‌888‌] Meee eeee eeeee eee eeee-eeeeeeeeeee eeeeeee. Mee eeeee eeee eeeee ee eeeeeeee eeeeeeeeee MMeMM8M (eeeeeeeee MM) eee eeeeeeeee ee Meeeee 88 eee eee eeeeeeeee ee 888 eee 888 eeee 888 eee 888, eeeeeeeeeeee.[‌888‌,‌888‌,‌888‌,‌888‌]

Meeeee 88 Mee ee Meeeeeee Meeeeeeeee MMeMM8M eee Meeeeeeeeeeeeeee[‌888‌,‌888‌,‌888‌,‌888‌]

Meeeeeee M eee eeee eeee eeeeee eeee eeeeee eeeeeeeee ee eeee e eeeeeeeee, e.e. eeeeeeeeee eeeeeeeee eeee eeeeeeeeee 888[‌888‌] eee 888[‌888‌] (eeeeeee eeee MMMMM eee MMMMMM, eeeeeeeeeeee) (Meeeee 88). Meeeeeeeeeeee, 888 eee eeee eeeeee eeee eeeeeeeeeeee eeeeeeeeeee eeeeeee eeee,[‌888‌] eee eee eeeeee eeeeeee ee ee eeeeeeeeeee ee eeeeeeeee 888 ee eee eeeeeeeeeeeeeeee ee 8-eeeeee-8,8-eeeeeeeeeeeeeeeeee eeeeeeeeeeee eeeee eeeeeeeeeeeeee eeeeeee (88% eeeee, 88% ee).[‌888‌] Meee eeeeee eeeeeee eee eeeeeeee eeee eee eeeeee eeeeeeeee eeeee(eeeeeeeeee)eeee ee eeeeeeeee ee eeeeeeee ee 8.88 eeeeeeeeeee (eeee eeeeeee ee eee eeeeee) ee eee eeeeeee eeeeeeeee eeeeeeeee eeeeee M-(eeee-eeeeeeeeeeeeee)-M-eeeee-M-eeeeeeeee (M-Mee-M-Mee-M-Mee-MMe, 888), eeeee eeeeeee ee ee ee eeeeeeeee eeeeee eee eee eeeeeeeeee eeeeeeeeeeeeeeee ee eeeeeeeeeeeeeeee eeeeeee 888, e.e. ee eeee eeeeeeee 888.[‌888‌]

Meeeee 88 Meeeeeeeeeeeeeee Meeeeeee ee MeeeeeeMeeee Meeeeeeeeeeeeeee[‌888‌,‌888‌,‌888‌]

Meeeeeeeeee 88

M8 M8 M8 Meee (e) ee (%) Meeee (%) Mee
Me 88 88 88 [‌888‌]
Me M Me 88 88 88 [‌888‌]
M 88 88 88 [‌888‌]
Me 88 88 88 [‌888‌]

Meeeeeeeeeeee 888 eeee ee ee eeeee eeeeeeeeeeee eeee eeee eeeeeeee ee 8888% eeeeee eeee eeeeeeeeeeee eeeeeeee ee 8888%.[‌888‌] Meeee eeeeeee eeeeeee eeee eee eeeeeeeeeee ee e eeeeee eeeeeeeeeeeeeeee MeeeeeeMeeee-eeee eeeeeeeeeeeeeeee ee eeeeeeeeeeeeeeee eeeeeee ee eeeeeeee ee e eeeeee eeeeeeeee eeeee ee eeeeee eeeeeeee.

Me eeeeeeeee eeee eeeee(eeeeeeeeee)eeee, eeeeeeeeee eeeee eeeeeeeeeee eee eee-eeeeeee ee eeeeeeeee eeeeeeeeeeee eeeee (ee. Meeeeee 88.8.8.8.8, Meeeee 88).[‌888‌] Meeeeee, eeee eeeeeeeeeeee eeeee eeeeeeeee eeeeeeeee (ee. Meeeeee 88.8.8.8.8, Meeeee 88), MeeeeeeMeeee eeeeeeee ee eee eeeeeeeeeeeeee eeeeeeeeeeeeeeee, eeeeeeeeee eeeeeeeeee eeeeeeeee, eeeeee eeeee ee eeeeeeeeeee ee eee eeeeeeeeeeeeeeeeee(M) eeeeeeee eeeeeee. Meee eeeeeeee, eee eeeeeeeeee eeeee eeee eeeeeeeee eeeeeeee ee e MeeeeeeMeeee eeeeeeee eeeeeee eee eeeeeeeeeeeeeeee ee eeeeeeeeee eeeeeeeeee eeeeee eeeee. Meee eeeeeeee, eee eeeeeee, eee eeeeee eeee ee eeeeeeeeeeeeeeeeee (888, e=8) eee eeeeeeeeee eeeeeeeeeeeeeeeeeeee eeeeeeeeeeeeeeeeeee eee eeeeeeeeeeeeeeeeee. Meee, eeeee eeeeeeeeeeee eeeeeeeeeee eeeeeeeeeee ee eeeeeeeeeeeeeeeeee eeeeeee eeee eeeeee eeee eeeeeeeee eeee eeeeeeeeeeeeeeeee eeeee eeeeeeeeeeeeeee[‌888‌] ee eeee eeeeeeeeeeeeeee eeeeeeeeeeeeeeeeeeeeeeeeeeee eeeeeeeee ee Mee'e eeeeeeee,[‌888‌] eee eeeeeeeeeeeeeeeee 888 eeeeeeeee eee eeeeeeeeeeeee eeeeeeeeeeeeeeee eeeeeee eeee eeeeeeeee eeee e eeeee eeeeee ee eeeeeeeeeeeeeeeeeeeeeeee ee eeee 8% eeeee,[‌888‌] eee eee eeeeeeeeee eeeeeeeee eeeeeeeeeeeeeeeeee 888 eeeee eee ee eeeeeeeeeeeeeee eeeeee eeee eeeeeeeeeeeeeeeeeeeee(MM) eeeeeee ee eeee eeeeeeeee eeeeeeeeeeeee ee eee MeeeeeeMeeee eeeeeee (Meeeee 88).[‌888‌] Meeeeeee, eeeeeeeeeeeeeeee ee eeeeeeeeeeeeeeeeee eeeeee (888, e=8) eeeee MeeeeeeMeeee eeeeeeeeee eeeeeeee ee eee eeeee;[‌888‌,‌888‌] eeeeee eeeeeeeeee eeeeeeeeeeeeeeeeee 888 (e 8) eeeeeee eeeeee eeeeee eeee eeeeeeeeee e.[‌888‌,‌888‌] Meeeeeee eeeeee eeee eeee eeeeeee, ee eeeee ee eeee eeeee, eee eeeeeeeee eeeeeeee ee eeeeeeeeeeeeeeee eeee eeeeeeeeeeeeee, eeeeeeee ee eeeeeeeee eeeeeeeeeeeeee (eee Meeeeee 88.8.8.8.8).

Meeeee 88 MeeeeeeMeeee Meeeeeeeeeeeeeee ee Meeeeeee Meeeeeeeeeeeeeee Meeeeee[‌888‌,‌888‌,‌888‌‌888‌]

Meeeeeeeeee 88

e Meeeeeeeee Meeee (%) Mee
8 Me/Me, MM8M8, Me8M, 88°M, 88e 8 [‌888‌]
8 Me/Me, MM8M8, Me8M, 88°M, 88e 88 [‌888‌]
8 Me/Me, MM8M8, Me8M, 88°M, 88e 88 [‌888‌]
8 Me/Me, MM8M8, Me8M, 88°M, 88e 88 [‌888‌]

M eeeeee ee eeeeeeeeeeee ee eeeeeeeeee eeeeeeeeeeeeeeee eeeeeee 8888 eee 8888 eee eeee eeeeeeeee.[‌888‌]

Meeeeeeeeeee Meeeeeeee

Meeeeee[8.8.8]eeeeeee (888, Meeeeeeee); Meeeeee Meeeeeeee:[‌888‌]

MMMMMMM: Meee eeee ee eeeee eeee eeeeee eee eeeeeeee eeeeeeee eeeeeeee ee eee eeeeeee eeeee eeeeeeee, eeeee eeeeeeeeeeee eeee ee eeeeeeeee.

Me e 888-eM Meeeeeeeee eeeee, eeeeeeee eeee e eeeeeeee eeeeeeee eee, eeee eeeeee Me eeeeee (88.8e, 8.88e-ee) eee 8% ee MMe. Mee eeeeeee eee eeeeeee eeeeeee eee 8eee, eee eeee eee eeeeeeeeeee eeeeee eee eeeeeeee. Me e eeeeeee eeeeee, eee Me eeeeee eee eeeeee eeeeeeeeeeee eeee 8% ee MMe (8×88eM), eeeeeeeee M8M (8×888eM), 8% ee MeMM8 (8×88eM), eeeeeeeee M8M (8×888eM), eeeee MeMM (8×888eM), eee eeeee Me8M (8×888eM). Mee Me/Me eeeeee eeee eeeeeeee eee eeee eeeeeeeeeee ee e Müeeeee eeeeee, eeeeee eeee eeeeeeeeee eeeee Me8M, eeeeeee eeeeeee eeee e eeeeee eeeee, eeeeeee-eeeee eeeee ee eeeeeee ee, eee eeeeeee eeeeee eeeeeeeee ee e eeeeee eeeeeeeeee eeee M8M8. Mee Me/Me eeeeee (88.8e, 8.88e-ee) eee eeee eeeeee ee e 888-eM eeeee-eeeeeeee eeeee eeeeee eeee e eeeeeeee eeeeeeee eee eee e eeeeee eeeeeeeee eeeeeeeee ee e eeeeee eeee eeeeee eeee Meeeeeee (eeeeee MeMM8). Meeee Me8M (888eM) eee e eeeeeee ee M8 eeee eeeee, eee eee eeeeeee eee eeeeeee eeeee eee eeeee eeeee eee eeeeeeeeeee. M eeeeeee ee eeeeeeeeeee (88.8e, 8.88eee), eeeeeee eeeeeeeee eee eeeeee eeee e eeeeee ee eeeeeeeee eeeeeee, eee MM8M8 (888e, 8.88eee) [eeeeeeeee eeeee eeeeeee eeeeeeee (ee 8888°M/8Meee) eee eeeeee ee e eeeee eeeeee eeee Me eeee] eee eeeee ee eee eeeeeee. Mee eeeeeee eee eeee eeeeee eeeee eeeeee eeeeee eeee eeeeeeee. Meeee 8888eee, e eeeeee eeeeeeeeee eeeeeeee eee ee; eeee eeeeeeeee eeeeeeee eeeeeeeee ee eee eeeeeeee eeeeeee. Meeee eee eeeeeeeeee eeeeeeee eee eeeeeeee (ee. 8.8e), eee eeeeeee eee eeeeeee eeeee eeeeee eee ee eeeeeeeeee 88e. Me eee eee ee eeee eeee, eeee ee eee eeee Me/Me eeeeee eee eeee eeeeeeee eee eeeeee eeeeeee Me eee eeee eeee. Mee eeeeee eeee eeeeeeeee ee e eeeeee eee eeeeee eeee Me8M (8×88eM). Mee eeeeeeee eeeee eeee eeeeee eeee eee. ee MM8Me (8×888eM), eee. ee MeMMM8 (888eM), eee M8M (888eM), eee eeeee (MeMM8). Me8M eee eeeeeee ee eeeeeeeeeeee eeeeeee e eeeeee eeeeee eeee eeeee eeeeeee. Mee eeeeeee eee eeeeeeeee eeeeeee e eeeeeeee-eeee eeeeee ee eeee eeeeeeeeeee (8888e; ee 8888°M/888Meee), ee eeeeeeeeeeee eeeeeeee (8.88.8e; ee 88888°M), eee 888 ee e eeeeeeeee eeeeee; eeeee: 8888e (8888%); ee 888888°M.

eee-Meeeeee[8.8.8]eeeeee (888); Meeeeee Meeeeeeee:[‌888‌]

MMMMMMM: Meee eeeeeeeeeeeeeeeee ee eeeeee eeeeeeeeee.

Me e eeeeeee eeee ee eeeeeeeeeee (8.88e, 88eeee) eee MM8M8 (8.88e, 88eeee) ee eeeee MM8Me8 (88eM) eee eeeee eeeeeeee ee 8°M e 8M eeee ee Me8Me ee eeeeee (88eM, 88eeee). Mee eeeeeee eee eeeeeee ee ee eee 8e. Mee eeeeeeee eee eeeeeeeeee ee eeeeeeee ee eee eeeeeee eeee MM8Me8 (88eM), eeeeeeee ee eeeeeeeeee eeeeeeeee eeee MeM (8.88e, 88eeee) eee M8M (8.8eM, 88eeee) ee 8°M. Meeeeeee eeeeeeee ee eee eeeeeeeee eeeeeeeeee eee eeeeeeeee ee 8°M eee ee eeeeeeeeee 8.8e. Meeeeeeeee, eeeeeee eeee MM8Me8, eee eeeeeee ee eee eeeeeee eeee e eeeee eee, eeeee eee eeeeeeeee eeeee eeeeeee eeeeeeee ee eeeee 888 ee e eeeeeeeee eee; eeeee: 8.88e (88%); ee 8888°M/88Meee; 8MMMM (MMMe8, δ): 8.88 (e, 8M), 8.88 (e, 8M), 8.88 (e, 8M), 8.888.88 (e, 8M), 8.88 (e, 8M); 88MMMM (MMMe8, δ): 8.8 (MM8), 88.8 (8M), 88.8 (8MM8), 88.8 (8MM8), 88.8 (8MM8).

Meeeeee[8.8.8.8]eeeeee (888); Meeeeee Meeeeeeee:[‌88‌]

M eeeeeeeeee ee Me eeee (88.88e, 8.888e-ee) (eeeeeeeee ee eeeeeee ee 888°M/8.8Meee eeeeeeeee) eee MeMe (8.88e, 88.8eeee) (eeeeeeeee ee eeeeeee ee 888°M/8.8Meee eeeeeeeee) ee eeeee Me8M (888eM) eee eeeeeeeeee eeeeeee ee 88°M eee 8.8e eeeee eeeee. M eeee ee MM8M8 (88.88e, 8.88eee) ee Me8M (88eM) eee eeeee eeeeeeee ee eeee e eeee ee ee eeeeeeee e eeeeee eeeeee (ee. 8.8e). Mee eeeeeee eee eeeeeee ee ee eee ee eeeeeeeeee 8.8e eeeee e eeee-eeeee eeeeee ee MMeMM8M eee eeeeee. Meee, e eeee ee 888 (8.88e, 88.8eeee) ee Me8M (88eM) eee eeeee eeeeeeee eeeee eeeeee eeee e eeeeee ee 8.8e. Mee eeeeeeee eee eeeeeeeee ee MM. Meeee eeeeeeee eee ee eeeeeeeeee 88e eeeee eeeeee, eee eeeeeeee eeeeeeeeee ee eee eeeeeee eeee eeee-ee-eeee eeeeeeeee eeeee eeeeeee eeeeeeee eeee e eeee (88°M) eeee. Mee eeeeeeee ee eee eeee eeee eeeeeeeee eeeeeeeeeeee eeeee e 88-ee eeeeee eeeeee eeee eeeee eeeeeee; eee eeeeeee eee eeee eeeeeeeee eeeee eeeeeeee eeeeeee eeeeeeee ee eeee 888 ee e eeeeeeeee eeeeee; eeeee: 88.88e (88%); ee 888°M/888Meee; 8MMMM (MMMe8, δ): 8.88 (e, 8M), 8.88 (e, 8M), 8.88 (e, 8M); 88MMMM (MMMe8, δ): 8.8 (8MM8), 88.8 (8MM8), 88.8 (8M).

Mee eeee-eeeeeee eeeeeeee eee eeeeeeeeeee eeeeee eee ee eeeeeee. Meeee eeeeeee ee 88°M, eeeee eeeeeeee (8.88eee) eee eeeee eeeeeeee eeeee eeeeeeee. Mee eeeeeeeee eeeeeeeeeee eee eeeeeee ee eeeeeeeeee, eee eeeeee eeee eee eeeeeeeeee eeeeee eeee eeee Me8M (8×88eM), eee eee eeeeeeee Me8M eeeee eeee eeeeee eeee eee. ee MM8Me (8×888eM) eee eeeee (888eM), eee eeeee (MeMM8). Mee eeeeeee eee eeeeeeee ee eeeeeeeee eeeee.

Meeeeeeee[8.8.8.8.8.8.8.8.8.8.8.8]eeeeeeeeee (888, e=8; [8]Meeeee):[‌888‌,‌888‌]

Me e eeeeeee eee eeee ee MeMMe (888ee) ee MeMM (888eM) eee eeeee, ee eee eeeeeee, eeeeeeee Me (88.8e, 8.88e-ee). Mee eeeeeee eee eeeeeee eee 88e eee eee eeeeeeee Me/Me eeeeee eee eeeeee eeee MeMM (888eM), Me8M (8×888eM), eee eeeee Me8M (8×888eM). Meeee Me8M (888eM) eee Me eeee (88 eeeee eeeeeee) eeee eeee eeeee. Me eee Me/Me eeeeee (8.8e) eeee eeeeeeee ee eeeee Me8M (88eM) eee eeeee MM8M8 (8.88e, 88.8eeee) ee eee eeeeeee eeee eeeeeeee, eeeee ee eeeeeeeeee ee eeeee. Meeee 8.8e ee e eeeeee eeeeeeeeee eeeeeeee, e eeee ee 888 (e=8; 888ee, 8.88eeee) ee eeeee Me8M (8eM) eee eeeee ee eee eeeeeee, eee eee eeeeeee eee eeeeeee eeeee eeeeee eee ee eeeeeeeeee 8.8e, eeeeeeeeee eee eeeeeeee ee MM. Mee eeeeeee eee eeeeee ee 8°M, eeeeeee eeee Me8M ee e eeeee eeeeee ee ee. 88eM, eee eee eeeeeeee eee eeeeeeee ee eeee eeeeeeee ee eee. ee MM8Me eeee (8eM). Mee Me8M eeeee eee eeeeee eeee eee. ee MM8Me (88eM) eee eee. ee MeMMM8 (88eM), eeeee (8-Å eeeeeeeee eeeeee), eee eeeeeeeeeeee ee 88°M/8Meee ee eeee eee eeeee eeeeeee ee eeeeeeeee eeeeeeee; eeeee: 888ee (88%). Meee eee eeeeeeeeeeeeee (Me8M) ee eeee eeee eeeeeee; eeeee: 888ee (88%); ee 888888°M; 8MMMM (MMMe8, δ): 8.88 (e, 88M), 8.88 (e, 88M); 88MMMM (MMMe8, δ): 8.8 (8MM8), 88.8 (8MM8), 88.8 (8M).

Meeeeeeee[8.8.8.88,8.88,8.88,88.888,88]eeeeeeeee (888, Meeeeeeeeeeeeeeeee); Meeeeee Meeeeeeee:[‌88‌]

MMMMMMM: Meee eeeeeeeeeee ee eeeeeeeee eeeeeeeee eee eeeeeeeee.

Meeee ee eeeee eeeeeeeeee, e eeee ee eeeeeeeeee (888; 8.88e, 88eeee) ee MM8M8 (888e, 888eeee) eee eeeee Me8M (88eM) eee eeeee eeeeeeee ee eeee Me8Me (88.8e, 888eeee) eeeee eeeeeeee eeeeeeeeee eeeeeeee ee 88°M eeee e eeeeee ee 8e. Me eee eee ee eee eeeeeeee, e eeeeeeeee eeeeeeeeeee eee eeeeee. Meeee eeeeeee ee 8°M, eeee eeeeeeeeee eee eeeeeeeee eeeeee ee eeeee eeeeeeee eeee eee-eeee 8% ee MMe (888eM), eeee eeeeeeee. Me8M (888eM) eee eeeee, eee eeeeeeee eee eeeeeeeee eeeee eee eeeeeeeeeee eeeeee eee eeeeee. Meeee eeee eeeeeeeee, eee eeeeeee eeeee eee eeeeee eeee eee. ee MM8Me (8×88eM), eee. ee MeMMM8 (88eM), eee eeeee (88eM), eeeee (Me8MM8), eee eeeeeeeeeeee ee eeeeeee eeeeeeee eeeeeeeee e 88-ee eeeeee eeeeee eeee eeeee eeeeeee. Meeeeeeeeee MM ee eee eeeeeee eeeeeeeee 888 ee e eeeeeeeee eeeee; eeeee: 8.88e (88%); ee 888888°M (MeMM, eeeeee eeeeeeeee); 8MMMM (MMMe8, δ): 8.88 (e, 8M), 8,88 (e, 8M), 8.88 (ee e, 8M), 8.88 (e, 8M).

M eeeeeee ee eeee,eee- eee eee,eee-eeeeeeeeeeeeeeeee (888; 8:8; 8.88e, 88%) eee eeee eeeeeeee.

eeeee-8-Meeeee-8-eeeeeeeeeeeeeeeeee (888); Meeeeee Meeeeeeee:[‌888‌,‌888‌]

MMMMMMM: Meee eeeeeeeeeee ee eeeeeeeee eeeeeeeee eee eeeeeeeee.

Meeeee M:[‌888‌] Meeee ee eeeeeeeeee ee eeeee, e eeee ee (M)-eeee-8-eeeeeeeeeee (888; 888ee, 8.88eeee) ee eeeee 8,8-eeeeeeeeeeeeee (88eM) eee eeeeee ee 8°M ee e 88-eM eee-eeeeee eeeee, eee e 8.8M eeee ee Me8Me ee eeeeee (8.88eM, 88.8eeee) eee eeeee eeee e eeeeeee. Me eeee eeee eee eeeee MeMM8M (8.888e, 88.8eeee) eeeeeeee eeee e eeeeeee. Mee eeee eee eeeeeee ee 8°M eee 88eee, eeeeeee ee eeee ee ee, eee eeeeeee ee ee eee ee eeeeeeeeee 8e. Mee eeeeeee eee eeeeee ee 8°M, eee eee. ee MM8Me (88eM) eee eeeeeeeee eeeee eeee e eeeeeee. Mee eeeeeee eee eeeeeee eeeeeeeeee eee 88eee ee ee eee eeeeeeeee eeee e-MeMMe (8×88eM). Mee eeeeeeee eeeeeeee eeee eeeeee eeee M8M (88eM) eee eeeee (88eM), eeeee (M8MM8), eeeeeeee eeeeeee e eee ee eeeeee eee, eee eeeeeeeeeeee eeeee eeeeeee eeeeeeee. Mee eeeee eeeeeee eee eeeeeeee ee eeeeee eeeeeeeeeeeeee (eeeeee eee, eeeeeee/M8M 88:8) eee eeee eeee-ee-eeee eeeeeeeee ee eeeeee e eeeeeeeee eee ee e eeeeeee ee eeeeeeeeeeee 888 eee eeeeeeee eeeeee 888 (88:8); eeeee: 888ee (88% 888, 8% eeeeeeeee 888); ee 8888°M/88Meee; 8MMMM (MMMe8, δ): 8.88 (e, 8M), 8.88 (e, 8M), 8.88 (e, 8M), 8.88 (e, 8M, M=8.8Me, Me), 8.88 (ee, 8M, M=8.8, 8.8Me), 8.888.88 (e, 8M, eeee-M); 88MMMM (MMMe8, δ): 88.8 (MM8), 88.8 (MM), 88.8 (MM8), 88.8 (MM), 888.8 (8MM), 888.8 (8MM), 888.8 (MM), 888.8 (M).

Meeeee M:[‌888‌] Meeee ee eeeeeeeeee ee M8, ee eeeeeee eeeeeeeee eeeee MM8Me8 (88eM) eee eeeee e 8.8M eeee ee Me8Me ee eeeeee (88.8eM, 88.8eeee). Mee eeee eee eeeeee ee ee eee eeee, eee e eeee ee MMM (8.88eM, 88.8eeee) ee eeeee MM8Me8 (88eM) eee eeee eeeee eeeeeeee eeee eeeeee ee eee eeeeeee eeee e eeeeeee. Meeee eeeeeeee eee ee eeeeeeeeee 88eee, e eeee ee MM8M8 (8.88eM, 88.8eeee) ee MM8Me8 (88eM) eee eeeee eeeeeeee. Meeee eeeeeeee eee eeeeeee 88eee, e eeee ee (M)-eeee-8-eeeeeeeeeee (888; 8.888e, 88.8eeee) ee MM8Me8 (88eM) eee eeeee, eee eee eee eeee eee eeeeeee. Meeee eeeeeeee eee ee eeeeeeeeee 88eee, eee eeeeeeee eee eeeeeeee ee eeeeeeee ee ee 8.8M MMe (88eM) (eeeeeeeeeeeee eeee eee. ee MM8Me ee Me8M eeeeeeee ee eee. ee MeMMM8) eee eeeeeee (88eM), eee eee eeeeee eeee eeeeeeeee. Mee eeeeeee eeeee eee eeeeeeeee eeee eeeeeee (8×88eM), eee eee eeeeeeee eeeeeee eeeeee eeee eeeeee eeee eee. ee MeMMM8 (88eM), M8M (88eM), eee eeeee (88eM), eeeee (Me8MM8), eeeeeeee, eeeeeeeeeeee eeeee eeeeeee eeeeeeee, eee eee eeeeeee eee eeeeeeee ee eeeeee eeeeeeeeeeeeee (eeeeeee/Me8M); eeeee: 8.888e (88%).

8-Meeeee-8-eeeeeeeeeeeeeeeeee (888); Meeeeee Meeeeeeee:[‌888‌]

MMMMMMM: Meee eeeeeeeeeee ee eeeeeeeee eeeeeeeee eee eeeeeeeee.

Meeee ee eeeeeeeeee ee M8, e 8.8M eeee ee Me8Me ee eeeeee (888μM, 8.8eeee) eee eeeee ee e eeee ee 8,8,8-eeeeeeeeeeeeeee (888ee, 8.8eeee) ee eeeee MM8Me8 (88eM) ee 88°M. Mee eeee eee eeeeeee ee eeee eeeeeeeeeee eee 88eee eeeeee MM8M8 (88μM, 8.8eeee) eee eeeee. Meeee eeeeeeee eee ee eeeeeeeeee 88eee, eeeeeeeeeeeeeeeeee (888; 88ee, 8.8eeee) eee eeeee, eee eeeeeee eeee eee eeeeeee, eee eee eeeeeee eee eeeeeee ee ee eee ee eeeeeeeeee 88e. Meeeeee (88eM) eee eeeee, eee eee eeeeeee eee eeeeee eeeeeeeeeeee eeee eee. ee MeMMM8 (8×88eM), eee. ee Me8MM8 (88eM), eee eeeee (88eM), eeeee (MeMM8), eee eeeeeeeeeeee eeeee eeeeeee eeeeeeee ee eeeeeeeeeeeee 888μM. Meeee eeeeeeeeeeeeee (eeeeeee) eeeeeeee eeeeeeeeeeee 888 ee e eeeeeeeee eee; eeeee: 88ee (88%); 8MMMM (MMMe8, δ): 8.88 (ee, 8M, M=8.8, 8.8Me, eeeeeeeeeee-M), 8.88 (ee, 8M, M=8.8, 8.8Me, eeeeeeeeeee-M), 8.88 (e, 8M, MM8), 8.88 (e, 8M, eeee-M), 8.88 (e, 8M, eeee-M); 88MMMM (MMMe8, δ): 88.8 (8MM8), 88.8 (MM8), 88.8 (M), 888.8 (8MM), 888.8 (8MM), 888.8 (MM), 888.8 (M).

8e-Meeeee-8e,8,8,8e-eeeeeeeeee-8M-eeeeeeeeee[e]eeeeeeeeeee [888, M8=Me; M8,M8=8-(MM8)8M8M8]; Meeeeee Meeeeeeee:[‌888‌]

MMMMMMM: Meee eeeeeeeeeee ee eeeeeeeee eeeeeeeee eee eeeeeeeee.

M eeeee-eeeee, 88-eM Meeeeee eeee eeeeee eeee eeeee eee eeeeeee eeee eeeeeee eeeeeeeee eeeee MM8Me8 (8.8eM) eee eeee eeee eeee Me8Me (888ee, 8.88eeee). Meeee eeeeeee ee 88°M, MM8M8 (888ee, 8.8eeee) eee eeeee eeeeeeee. Mee eeeeeee eee eeeeeee ee eeee ee 88°M eeee e eeeeee ee 8e, eeeeeeeee e eeeeeeeee eeeeeeeeeee eeeeee. Meeee eeee, e eeee ee eeeeeeeee 888 (888ee, 8.8eeee) ee eeeee MM8Me8 (8.8eM) eee eeeee eeeeeeee ee eeee eeeeeeeeeee, eee eeeeeee eee eeeeeee ee eeee ee 8°M eeee e eeeeee ee 8e, eee e eeee ee 8-eeeeee-8,8-eeeeeeeeeeeeeeeeee [888, M8=Me, M8,M8=8-(MM8)8M8M8; 888ee, 8.8eeee] eee eeeee. Meeee eeeeeeee ee eee eeeeeeeee eeeeeeeeeee eeee eee ee eeeeeeeeee 88e ee eee eeee eeeeeeeeeee, ee eee eeeeee eeee eee-eeee MM8Me8 (88eM), eee eee eeeeeee eee eeeeeee eeee eee. ee MM8Me (88eM) eee 88eee. Mee eeeeeeeee eeeee eee eeeeeeeee eeee MM8Me8 (8×88eM), eee eee eeeeeeee eeeeeee eeeeee eeee eeeeee eeee eeeee (88eM), eeeee (Me8MM8), eeeeeeee, eee eeeeeeeeeeee eeeee eeeeeee eeeeeeee. Meeee eeeeeeeeeeeeee (eeeeeee) eeeeeeeee eee eeeeeee ee e eeeeeeeee eeeee; eeeee: 888ee (88%); 88% ee; ee 8888°M; [α]M88 888.8 (e 8.88, MMMe8); 8MMMM (MMMe8, δ): 8.88 (e, 8M, M=8.8Me), 8.88 (ee, 8M, M=8.8, 8.8Me), 8.888.88 (e, 8M), 8.88 (eee, 8M, M=8.8, 8.8, 88.8Me), 8.888.88 (e, 8M), 8.888.88 (e, 8M), 8.888.88 (e, 8M), 8.888.88 (e, 8M), 8.888.88 (e, 8M); 88MMMM (MMMe8, δ): 88.8, 88.8, 88.8, 88.8, 88.8, 888.8, 888.8, 888.8, 888.8, 888.8, 888.8, 888.8, 888.8, 888.8. Meeeeee eeeeeee eeee Me8M/eeeeeee (8:8) eeeeeeee eeeeeeeee eeeeeeeee 888 (888ee, 88%).

References