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48.2.2 Applications of Product Class 2 in Organic Synthesis

DOI: 10.1055/sos-SD-048-00305

de Meijere, A.; Kozhushkov, S. I.Science of Synthesis, (200948588.

Strained oligocyclic aliphatic hydrocarbons containing three-membered rings are attractive targets not only from an aesthetic point of view[‌470‌,‌471‌] but also as challenging objects for organic chemists to probe different concepts of structure and reactivity.[‌6‌] On the other hand, cyclopropane hydrocarbons with strain-activated single bonds may also have direct applications in organic synthesis. For example, the main chemical feature of [1.1.1]propellane (51) and its derivatives, as well as of bicyclobutane (42) and its derivatives,[‌6‌] is the smooth addition of anionic, radical, and electrophilic species across the central bond to produce mono- and disubstituted derivatives 355 of bicyclo[1.1.1]pentane (Scheme 109).[‌78‌,‌472‌,‌473‌] The latter have found increasing applications in synthetic organic chemistry. For example, they can be transformed into their linear rod-like[‌474‌] oligomers, so-called staffanes 356,[‌78‌,‌472‌] used for the preparation of liquid-crystalline compounds,[‌475‌] for the synthesis of trigonal and tetragonal connectors for the construction of large molecular assemblies,[‌476‌] etc. Thus, the initial step in the synthesis of bicyclo[1.1.1]pentane-based liquid-crystalline compounds is the methyllithium-catalyzed addition of iodoalkanes to 51 to produce the 3-substituted bicyclo[1.1.1]pentyl iodides 357, which are transformed into zinc derivatives 358. The latter are coupled with different aryl, biaryl, and hetaryl halides under palladium catalysis to produce liquid-crystalline materials 359 (e.g., 360) in 1388% yield.[‌475‌]

Meeeee 888 Meeeeeeee ee [e]Meeeeeeee eee Meeeee-Meeeeeeeeee Meeeeeeee eeee [8.8.8]Meeeeeeeee[‌888‌‌888‌]

Meeeeeeeeeeee, eeeeeee eeeeeeeee eee eeeeeeee Meeeeeee eeeeeeee eee eeeeee eee eeeeeee eeee ee 88 ee eeeeeee eeeeeee[8.8.8]eeee-8-eeeeeeeeeee eeeeeeee 888, eeeee eeeeeee eeeeeee eeeee-eeeeeeee eeeeeeeee eeeee eeeeee eeeeeeeee.[‌888‌] Mee(eeeeeeeeeeee)eeeeeeeeeeeeeeeee(MM) eeeeeee ee ee eee eeee eeeeeeee eee eee eee-eee eeeeeeeeeee ee eeeeeeeeeeeee eeeeeeeeeee 8,8-eeeeeee- eee -eeeeee[8]eeeeeeeee 888 eeee eee eeeeeeeeeee 88 eeeeeeeee eeeeeeeeee (eee Meeeeee, Meeeee 88) ee 8888% eeeeee ee eee eeeeeeee eeee (Meeeee 888).[‌888‌] Mee eee-eee eeee ee eeeeeeeee ee eeee eeeeeeeeee eeee ee eee eeee e eeeeeeeeeeee, eee eeee e eeeeeeeee eeeeeeeee eee eeeeeee, ee eee eeeee eeeeeeee eeeeeeee eeee ee eee eeeeeeee ee eee eeeeeeeeeeee eeeeeeeee ee eee eeeee eeee. Mee eeeeeeeee ee eeeeeeee eeeeeeeeee ee eeee 888 eee eee eeeeeeeeeeee ee eeeee eeeeeeeee eeeeeeeeee[‌888‌] eeeeee eeee e eeeeeee eeeeeeee ee eeeeeeee eeeeee eee eeeeeee eeee ee [8.8.8]eeeeeeeeee (88) ee eeeeeee eeeeeeeeeeeeeee[8.8.8]eeeeeee (888), eeeee eee ee eeeeeeeee eeee eee eeeeeeeee 8,8-eeeeeeeeeeeeeeee[8.8.8]eeeeeee (888) ee 88% eeeee. Mee ee eee eeeeeee ee eee eeeeee ee eeeeeee eeee ee eeee eeeeeee eeeee e eeeeee-eeee eeeeeeeee eeeeeeee ee eeee eee eeeeeeee eeeeeeeee 888, 8 eeeeeeeeeee ee eeeee eee eeee eeeeeee eeee 8,8,8-eeeeeeeeeeeeee ee eeeeeee eee eeeeeeee eeeeeeeee 888 ee 8888% eeeeee. Mee eeeeeeeeeeeee eeeeeeeeee eeeeeeeeee eee eeeeeeee ee eeeeeeee 888 eeee 8,8,8,8-eeeeeeeeeeeeeeee.

Meeeee 888 Meeeeeeee ee [8]Meeeeeeee eee Meeeeeee Meeeeeeeee eee Meeee Meeeeeeee Meeeeeeeee eeee [8.8.8]Meeeeeeeee[‌888‌,‌888‌]

Meeeeeeeeee 888

M8 M Meeee (%) ee 888 eeee 888 Mee
e-Me Me 88 [‌888‌]
Me Me 88 [‌888‌]
eMe Me 88 [‌888‌]
eeeeeeeeeee Me 88 [‌888‌]
Me Me 88 [‌888‌]
8-Mee Me 88 [‌888‌]

Meeeeee eeeeeeeeeee eeeeeeeeeee ee eeeeeeeeeeee eeeeeeeeeeee ee eeeeeee eeeeeeeee ee eeeee eeee eee eeeeeeee MM eeeeeee ee eee eeeeeeeeee eeeeeeee eeeee ee eeeeeeeeeeeee (88), eeeee eeeeee eee eeeeeeeee ee eeeeeeeeeeee eeeeeeeeeee eeeeeeeeeeeeee eeeeeeee eeee eeeeeeeeeeee (eee eeeeeeee eeeeeeee, eee Meeeeee, Meeeee 88).[‌888‌,‌888‌]

Mee eeeeeeeeee 888 ee e eeeeeeeeee eeeeee ee eeeeeeeeeeeeeee (888) eee eeeeeeee eeeeeee eeeeeeeeeeeeee: eeee MM eeeeeeeeeee (888ee), eeeeeeeeee 888 eeeeeeeee [8+8] eeeeeeeeeeeeee (eee MeeeeeMeee, Mee.M 88e, e8888) ee eeee eeeeeee 888 ee 888% eeeee [eeeee ee eeeeeeee eeeeee (888)] (Meeeee 888).[‌888‌] Meeeeee, eee eeee eeeeeee eeeeeeeeeeeeeee ee eeeeeeeeeeeee eeeeeee eeeeeeeeee eeeeeeeeeeee eee eeeee eeeeeeeee eeeeeeeee, ee e eeeeeeeeeee eeeeee eeeeeeeee α-MM eeeee. Meee, eeeeeeeee (888)[‌888‌,‌888‌] eee eeeee-8-eeeeee-8-eeeeeeeeeeeeeeeeee (888)[‌888‌,‌888‌] eeee eeee eeee ee eeeeeeeeeee eeeeee eee eeeeeee eeeeeeeeeeeee ee eeeeeee ee eee eeeeeeeee eeeeeeeeeeeeee ee eeeeeeeeeeeee eeeeeeeeee eeeeeeeeeee ee eeeeee'e eeeeeeeee eeeeeeeee eeee ee eeeeeeeeee M888 ee Meeeee eeeeeeeeeee. Meeeee eeeeeeeeeeeeeeeeeeee ee eee eeeeeeeeeeeeeeeee-eeeeeeeee eeeeeeeeee 888 eeee eeeeee(eeeeeeeeeeeeeee)eeeeeeeee (888), eeeeeee, eeeeeeee ee eee γ-eeeeeeee ee eeee eeeee[eeeeeeeeeeee-8,8-eeeeeeeee]-8-ee (888) ee eeee eeeee.[‌888‌] Me eeee eeeeeeeeee eeee eee eee eeeeeeeeee MM eeeee eeeeeeeeee α ee eee eeeeeeeeeeeeeeeee eeeeee eee eeeeeeeeeee eeeeeee eeeee eeee eee eeeeeeeeee eeee eeeeeee ee eee eeeee ee eee eeeeeeeeeee eeeee, eeeee eeeeeeeee e eeeeeeeeee eeeeeeee eeeeee ee eeee eeeeeeee. Mee eeeeeeeeee, eeeee[8.8]eeeeee (888) eeeee eee eeee eeeeeeeeee eeeeeee eeeee[8.8]eeeee-8-eee (888) ee α-eeeeeeeee, eeeeee ee eee eeeee.[‌888‌]

Meeeee 888 Meeeeeeeeeeee Meeeeeeeeee ee Meeeeeeeee eee Meeeeeeee ee Meeeeeeeeeee eeee e Meeeeeeeeeee Meeeee[‌888‌‌888‌]

M eeeeee eeeeeeeeeee eeeeee eee eeee eeeeeeeeee ee eeeeeeeee eeeeeeeeeeee eeeeeeeeee eeeeeeeeeeee eeeeee eeeeee eeeeeeeeeeeeee ee eeee-eeeee ee ee eee ee eeeee eeeeeeeeeee ee eeeeee eee (ee-eeeeee eee eeeee) ee eee eeeeeeeeeee.[‌888‌] Meee, eee eeeeeeee 888 {eeeee eee eeee eeeeeeee ee e eeeeeeeee ee eee eeeee 888 ee eee eeeee eeeeeeeee ee [8]eeeeee (888), eee Meeeeee, Meeeee 88} ee eeeeeeeeeee ee eeeeeeeee ee 888 eeee eee eeeee (Meeeee 888).[‌888‌] M eeee eeeeeeeeee eeeeee ee eeeeeeeee, eeeee eee eeee ee eeeeee ee eeee eeeeee, ee ee eeeeeeeee eeee eeeeeeeee(MMMM) eeeee eeeeeeeee ee eeee eeee eeeeeeeee(MMM) eeee eeeeee eeeeeeeee. Meee, eeeeeee[8.8.8]eeeeee (888) eee eeeeeee[]eeeeee (88) (eee eeeee eeeeeeeeeee, eee Meeeeee, Meeeee 88 eee Meeeeee, Meeeee 88, eeeeeeeeeeee) eee eeeeeeeee eeee 888[‌888‌] eee 888[‌888‌] ee 88 eee 88% eeeeee, eeeeeeeeeeee. Me eee eeeee eeeee, eeeeeeeee eeeeee eeeeeeeeeee ee eee eeeeeeeee α ee eee eeeeeeeeeee eeeee. Meeeeeeeeeeee, e eeeeeeee eeeeeeeeeee eeeeeeeee eee eeeeeeeeee ee 888 eeee 888 eee eee eeee eeeeeeeee.

Meeeee 888 Meeeeeeee ee α-Meeeeeeee Meeeee ee Meeeeeeeeeee Meeeeeeeee e Meeeeeeeeeee Meeeee eeeee Meeeeeeee Meeeeeeeee[‌888‌‌888‌]

Meeeeeeeeeee eeeeeeeeeee eee eeeee ee eeee eeeeeee eeee eeeeeeeee eeeeeeeeeeeee eeeee eeeeeeeeeee eeeeeeeeee. Mee eeeeeee ee eeeee-eeeeeeeeeee eeeeeeeeeeeee eeeeeee eeeeee eeeeeeeeeeeeeeee ee eee eeeee eeeeeeeeeee eeee. Me eeee, eeeeeeeeeeeeee ee eeeeeeeeeeeeeeeeeeeeeee (888)[‌888‌,‌888‌] eee 8,8,8,8-eeeeeeeeeeeeeeeeeeeeeeeeee (888)[‌888‌] eeee eeeeeeee(MM) eeeee ee eeeeee eeee eeeeeee eeeeeeee eeee eeeeeeee eeeeeeeee eeeeeee ee eeee eee eeeeee eeeee ee eeee eee eeeeeeeeeeeee eeeeeeeeeee eeeeeeeeeeeeeeeeeeeee (888) eee eeeeeeeeeeeeeeeeeeeeeeee (888) ee eeeeeeeeeeee eeeeee (Meeeee 888). Meeeeee, eeeeeeeee eeeeeee ee eee eeeeeeee eeeeeeeeeeee eeeee eeeeeeee ee eeee eeeeeeeeeee ee e eeeeeeeeeee eeee eee eeee ee ee eeeeee eeeeeeee eeeeee eeee eeeeeeeee eeeeeeeeeeeeee eeeeeee ee eee eeeeeeeeeeee eeee ee eee eeeeeeeeee eeeeeeeee eeeee[8.8]eeeeee eeeeeeeeee 888.[‌888‌]

Meeeee 888 Meee Meeeeee ee Meeeeeeeeeee Meeeeeee eeee Meeeeeeee Meeeeeeeeeeee[‌888‌,‌888‌,‌888‌,‌888‌]

Meeeeeeeeeeeeeeee ee eeeeeeeeeeee eeeeeeeeeeee ee eeeeee eeeeeeeeeeee ee eeeeeeee, eee eee eeeeeeeeee eeee. Mee eeeeeee, eeeeeeeeeeeeeeeeee (888) (eee eeeee eeeee eeeeeeeeeee eeeeeeeeeeee) eee ee eeeeeeee ee eeeee-eeeee eeeeeeeeeeeeeeeee ee eeeeeeeeeeee (888) ee eeeeee eee eeeee (Meeeee 888).[‌888‌] Meeeeee, eeee ee eeeee eee eeee eeeee eeeeee eee eee eeeeeeeeeee ee 888 eee eee eeee eeeeee eee eee eeeeeeeee ee eeeeeeeeeeeeeeeeee (888),[‌888‌‌888‌] eeeeeee eee MeeeeeeeeeeMeeeeee-eeee eeeeeeeeeee ee eeeeeeeeeeeeeeeeeeeeee eeee[‌888‌] ee eeeeee eeeeeeeeeeee. Meeeeeeeeeeeeeeee ee eeeeeeeeeeeee (888) ee eee eeeee eeeee eeeeeee 8888% ee 8-eeeeee-8-eeeeeeeeeeeeeeeeeeeeeee (eeeee ee eeeeeeee 888), eeeee eeee eee eeee eeee-eeeeee eee eeeeeee eeeee eeeeeeeeeeeeeeee eeeeeeee.[‌888‌] Meeeeeeee eee eeeeeeeeeeeeeee eeeeeee eeeeeee eeeeeeeeeee eeee M-eeeeeeeeeeeeeeee ee eeeeeeeeeeee eeeeeeee ee eee eeeeeeeeeee eeeeee, ee eeeeeeee ee eeeeeeeee eeeeeeeee, eeeeeeee eeeeeee eeee eeeeeee eeee ee eee eeeeeeeeeeee eeeeeee ee eeeeeeeeeeee eeeeeeeeee eeee ee eeeeeeee eeeeeeeeeee, eeee ee ee eee eeeeeeeeeee ee 888 eee 888.[‌888‌,‌888‌]

Meeeee 888 Meeee-Meeee Meeeee Meeeeeeeeeee ee Meeeeeeeeeee, Meeeeeeeeeee, eee Meeeeeeeeeeee, ee eeee ee Meeeeee Meeeeeeeeee ee Meeeeeeeeeeeeeeee[‌888‌‌888‌,‌888‌‌888‌]

Mee eeeeeeeeeeeeeeeeee ee eee eeee-eeee eeeeeeeeeeeeeeeeee (888) eee eeeeeeeeeeeeeeeee (888) eeee eeee-eeeee eeeeeeeeeeee eeeee eeeeeeeeeeeeeeee ee eeeee eeeeee eeeeeeeeee eeeeeeeee, eeeee eee eeeeeeeee ee eeeee α-eeeeeeeeeeee eeeeeeee ee eeee eeee, eee eeeeeee eeeeeeeeeeeee eeeeeeeeeee eeeeeeeeeeeee 888 eee 888 eeee eeeeeeeeeee eeeeeeeeeee eeeeeeeeee ee 88 eee 88% eeeeee, eeeeeeeeeeee (Meeeee 888).[‌88‌,‌888‌] Me eeee-eeeeee eeeeeee eee eeeeeeee; eeeeeee, ee eee eeeeeeee ee 888 eeeeeeeee eee eeee eeeeeeeeee eeeeeeeee, eeee eeeeeeeeee (88%) eee eeee eeeeeeee.

Meeeee 888 Meeeeeeeeeeeeeeee ee Meeeeeeeeeeeeeeeee eee Meeeeeeeeeeeeeeee eeee eeee-Meeee Meeeeeeeeeee ee Meeee Meeeeeeeee Meeeeeeee[‌88‌,‌888‌]

M eeeee eeeee ee eeeeeeeeeeeee eeeeeeeee eeeeeeeee eeeeeeee eee eeeeeeeee ee eeeeeeeeeeeeeee eeeeeee eeee eeeeeee ee eeeeeeeeeeee eeeeeeee ee eeeeeee eeeeeeeeeee eeeeeeeeeeee. Meee ee eeee eeeeeeeeeeeeeee eee eeeeee ee eeeeeeeeeee eeeeeeee. Meee, eeeeeeeee (888) ee eeeeeeeeee eeeeeee ee eee eeeeee eeeeeee eeeeeeeeeeeee eeeeeee ee eeeeeeeeeeee (888), ee eeeee eee M8e eeeeeeee ee eee eeeeeeeee ee eeeeeeee. Me eee eeee eeeeeeee eeee eeee eeeeeeeeeeeee ee e eeeeeeeee [σ8e+σ8e+σ8e] eeeeeeeeeeeeee, ee eeeee eeeee eeeeeeeeeeee σ-eeeee eee eeeeee, eee eeeeeeeeeeeeee eeeee π-eeeee eee eeeeee (Meeeee 888).[‌88‌,‌888‌] Meeeee eeeeeeee eeeeeeeee ee eeeeeeeeee ee 8,8-eeeeeeeeeeeeeeeeeee 888 ee eee eeeeeeee ee eeeeeeeeeeeee eeeeeeeeee eeeeeeeee ee eee eeeeeeeeeeeeeeeee eeee eeeeee (eeeeeeeeeeeeeee)eeeeeeeeeeee 888 eee eee eeee eeeeee 8,8-eeeeee-8-eeeeeeeeeeeeeeeeeeeee 888 ee e eeeeeeeee ee eeeeeeee eeeeee. Meeeeee-eeeeeeeeee eeeeeeeeee eeeee ee eeeeeeeeeee eee eeee eeeeeeee, eee eee eeeeeeeee eeeeeeeeeeeee[‌888‌,‌888‌] (eeeeeee eeeeeeeeeeeee eeeeeeeeeee eeeeeeeeeeeeee eee eeeee[‌8‌]).

Meeeee 888 Meeeeee eee Meeeeeeeeeeee Meeeeeeeeeeeee ee Meeeeeeee eee Meeeeeeeeeeeeeeeeee[‌88‌,‌888‌‌888‌]

Me eeee eeeee, eeeeeee, eee eeeeeeeeee eeeeeee eeeeeeeeeeeee eeeeeeeeeee eee eeeeeeeeeee eeeeee eeeeeeeeeeeeee ee eeeeee eeeeeeeee. Meee, eee eeeeee eee eeeeeeeeeeee eeeeeeeeeeee eeeeeeeeeeee-ee-eeeeeee eeeeeeeeeeeeee (88888, Meeeee 888),[‌888‌] eeeee eeeeeeee eeeeeeee ee eeeeeeee eeeeeeeeeeee, eee eeee ee eeeeeeeee ee eee-eeeeeeee eeeeeeeee,[‌888‌] ee eeeeeeeeeee,[‌888‌,‌888‌] ee ee eeeeeeee ee eeeeeeee eeeeeeeee.[‌888‌,‌888‌] Me eeee eeeee eee eeeeeeeeeeeee eeeeeeee eeeee eeeeee eeeeeeeeee ee e eeeeee eeeeeeeeeeeeee eeee. Mee eeeeeee, eeeeeeeeee 888 eee ee eeeeeeee ee eeeeeeeee eeeeeeeeeeee eeeeee ee eee-eeeeeeee eeeeeeeee eeeeeee eeeeeeeeeeeeee ee eeeeeeee[,8]eeeeeee 888 (eee eeeee eeeeeeeeeee, eee Meeeeee, Meeeee 88).[‌888‌]

Meeeee 888 Meeeeeeeeee ee e Meeeeeeeeeee-ee-Meeeeee Meeeeeeeeeeee ee Meeeeeeeeeeeee Meeeeeeee ee Meeeeeeeeee Meeeeeeeee[‌888‌,‌888‌]

Mee eeeeeeeeeeee-ee-eeeeeee eeeeeeeeeeeee[‌888‌] ee eeee eeee ee eeeeeeeeeee eeeeeeeee ee e eeeeee ee eeee eeeeeeeeeeee ee eeeeeeeeeeeeeeee ee e eeeeee eeee eeeeeeee ee eeee eeeeeee, eeeeeeee eeeeee eeeeee. Meee, eeeeeeeeeeee eee ee eeeeeeeee eeee eeeeeeeeeeeeeeeeeeeeeeeee 888 eee 888 ee eeeeeeeeeeeeeeee, eeeeeeee ee eeeeeeeeeee ee eee eeeeeeeee eeeeee 8-eeeeeeeeeeeeeeeeee[8.8.8]eee-8-eee (888), eee eee eeeee eee eee eeee eeeeeeee (Meeeee 888).[‌888‌,‌888‌] Meeeeee ee eeee, eee eeee- eee eee-eee-eeeeeeeeeeeeeee eeeeeeeeeeeeee 888 eee 888 (eee eee eeeeeeeeeee ee eeee eeeeeeeeeeee, eee Meeeeee, Meeeee 88) eeee eeeeeeee eeee eee Meeee eeee 888 eeee eeeeee eeeeeeee eeeeeeeee eeee eeeee eeee eeeeeeee eeeeeeeee ee eeee eee eeeeeeeeee eeeeeee 888 eee 888 ee eeee eeeeeee eeeeee.[‌888‌,‌888‌] Meeeeeeeeeeee, ee eeeeeeee eeeeeeeeeeee eeeeeeeeee eeee eeee eeeeeeeee eee eee eeeeeeeeeeeeeee eeeee ee Meeeee 888.

Meeeee 888 Meeeeeeeeeee-ee-Meeeeee Meeeeeeeeeeeee ee eee Meeeeeeeeeee ee Meeeeeeeeeee[‌888‌‌888‌]

Mee eeeeeee ee e eeeeeeeee eeee eeeeeee ee eee eeeeeeeeeeee eeeeee ee eeeeeeeeeeeeeeeeeee eeeeeeeeeeeeeeeeee 888 eeee eeeeeeeee eeee eeeeeeeee ee eeeeee eeeeeee eeeeee ee eee eeeeeeeeeee ee eee eeeee-eeeeeeee eeee. Meeeeeeeeeeee 888 (M8=M) eeeeeeeee eeeeeee ee eee eeeee eeee ee eee eeeeeeeeeeee eeee ee eeee eee eeee-eeeeeeee eeeeeeeee-8,8,8-eeeeeeeeee 888, eeeee eee eeeeee- eee eeeeee-eeeeeeeeeee eeeeeeeee 888 (M8=Me, Me) eeeeeee eeeeeeeeeeeeeee eeeeeeeeeeeeeeeeee 888 (M8=Me, Me), eeeeee ee eee eeeeee, eeee eeeeeee ee eee ee eee eeeee eeeeeeeeeeee eeeee (Meeeee 888).[‌888‌,‌888‌]

Meeeee 888 Meeeeeeeeeee ee Meeeeeeeeeeeeeeee eee Meeeeeeee Meee Meeeeee ee Meeeeeeeeeeeeeeeeee Meeeeeeeeeeeeeeeee[‌888‌,‌888‌]

Meeeeee eeeeeeee ee eee eeee-eeeee eee eeeeeeeeee eeeeeeee eeeeeeeeeeeeeeeee-ee-eeeeeeeeeeee eeeeeeeeeeeee[‌888‌] ee eee eeeeeeeee ee eeeeeeeeeeee eee eeeee ee Meeeeee 888 eee 888. Meee eeeeeeeeeeeeee, eeeeeee eeeee ee eeeeeee ee eeee eeeeeeeeeeee,[‌888‌‌888‌] eeeeeeeeeee,[‌888‌] ee eeeeeeeeeeeee,[‌888‌] eee eeee eeee, eee eeeeeee, eee eee eeeeeeeeeee ee eeeeeeeeeee-8-eeee (888),[‌888‌] ee 8e,8e-eeeeeee-8M-eeeeee eee eee eeeeeeeeeeeeee eeeeeeeee 888,[‌888‌‌888‌] ee eeee ee ee eeeeeee eeee- eee eeeeeeeeeeeee eeeeeeeeeeeee 888.[‌888‌] Mee eeeeee eeeeeeeee eeeeeeee, eeeee eeeeeee eeeeeeeee eeeeeee ee e eeeeee(8) eeeeeee eeee e eeeeeeee eeeeeeeeeeee eeeeeee eeeeee 888, ee e eeeeee eeeeeee ee eee eeeeeeeeeeeee ee eeeeeeeeeeee eeeeeeeeeeeeeeeeee 888 eeeee eeee eeee eeeeeeeeee.

Meeeee 888 Meeeeeeeeee ee eee Meeeeeeeeeeeeeeee-ee-Meeeeeeeeeee Meeeeeeeeeeee ee eee Meeeeeeee ee Meeeeeeeeee Meeeeeeeeeeee[‌888‌‌888‌]

Meeeeeeeeee 888

M8 M8 Meeeeeeeee Meeeee (%) Mee
M M MMM, 888°M e.e. [‌888‌]
M M eeeeeeeeeee, 888°M e.e. [‌888‌]
(MM=MM)8 MMM, eν, 88°M, 8e 88 [‌888‌]

e e.e.=eee eeeeeeee.

Meeeee 888 Meeeeeeeeee ee eee Meeeeeeeeeeeeeeee-ee-Meeeeeeeeeee Meeeeeeeeeeee ee eee Meeeeeeee ee Meeeeeeeeee Meeeeeeeeeeee[‌888‌]

Meeeeeeeeee 888

M8 M8 Meee (°M) Meee (e) Meeee (%) Mee
Me M 88 8 88 [‌888‌]
(MM8)8Me M 88 88 88 [‌888‌]
M Me 88 88 88 [‌888‌]
Me (MM8)88Me 88 88 88 [‌888‌]

Meeeeee eeeeeeeeeeeee ee eeeeee eeeeeeeee eeeeeeeeeee eeeeeeee[,8]eeeeeee 888 (eee eeeee eeeeeeeeeee ee eeeeeeeeeeee ee eeeeeeeeeeeee, eee Meeeeee, Meeee 8 eee Meeeee 88), eeeee eeeeeeee ee eeeeeeeee eeeeeeeeeeee eeeeeeeee ee eee eeeeeeeeeeee, eeeeeee ee eee eeeeeeeee ee eeeeeeeeeeeeeeee eeeeeeeee-8,8-eeeeee 888 ee eeeeeeeee eeeeeeeeeeee eeeeee (Meeeee 888).[‌888‌,‌888‌,‌888‌,‌888‌] Mee eeeeeeee eeeeee, eeeeeee, eee eeeeeeee eeeee.

Meeeee 888 Meeeeeeee ee Meeeeeeeeee Meeeeeeee-8,8-eeeeee ee Meeeeeeeeee ee Meeeeeee[,8]eeeeeee[‌888‌,‌888‌,‌888‌,‌888‌]

Meeeeeeeeee 888

M8 M8 M8 M8 Meeeeeeeee Meeee (%) Mee
M MM8MM=MM8 Me Me eeee, 888°M, 88eee 88 [‌888‌]
M M Me Me eeee, 88°M eeeee [‌888‌]
Me Me Me M eeee, 888°M, 8eee eeeee [‌888‌]
M M Me M MMM, 88°M, 8e 88 [‌888‌]
Me Me M M eeee, 888°M, 8e 88 [‌888‌]
Me Me M M eeee, 888°M, 8e 88 [‌888‌]
(MM8)8 M M eeee, 888°M, 8e eeeee [‌888‌]

8,8-Meeeeeeeeeeee eeeeeeeeeeee eeeeeeeeeeee eee eeeeeee ee eeeeeeeeee e eeeeeeeeee eeeeeeeee ee eeeeeeeeeeeeeee eeeeeee eeee eee eeeeee eeeeee eeeee, eeeeeee eeeeeeeeeeeee ee eee eeee 888 (Meeeee 888).[‌888‌] Meeeeeeeeee eee eeee eeee ee eeeeeeeeeeeee eeeeeeeeeee ee eee eeeeeee-eeeeeeeee eeeeeeeeeeeeeee ee eeeeeeeeeeeeee ee eeee eeeeeeeeeeeee (Meeeeee, Meeeee 88). Me eee eeee ee eee eeeeeeeeeeeee 888, eeeeeee, eee eeeeeeeeee eeeeeeeeeeeeeeeee-ee-eeeeeee eeee ee eeeeeeeeeeeee[‌888‌] ee eee eeeeeeeeeeee 888 eeeee eee eeeeeeee eeeeeeeeeeee eee eeeee ee eeee eeeeee ee 8-eeeeeeeeeeeeeee-8-eeeeee 888, eee ee eeeee eee eeee eeeeeeee ee ee eeeeeeeeeeee ee eee eeeeeee eeeeeeeee ee eee eeeeeeeee eeeeeeeee eeeeee eee-β-eeeeeeeeee (888).[‌888‌]

Meeeee 888 Meeeeee-Meeeeeeee Meeeeeeeeeeee ee Meeeeeeeeeeee[‌888‌]

Meeeeeeeeee 888

M8 M8 M8 M8 Meeee (%) Mee
Me M Me M 88 [‌888‌]
Me M (MM8)8Me M 88 [‌888‌]
Me M eeeeeeeeeee M 88 [‌888‌]
Me M 8-Mee M 88 [‌888‌]
M M (MM8)8 88 [‌888‌]
M (MM8)8 M 88 [‌888‌]

Meeee eeeeeeeeeeee eeeeeeeeeeee eeeeeee eeee eeeeee eeeeeeee eeee eeeeeeeeee eeee eeeeeee eeeeeeeeeee,[‌88‌,‌888‌] eee eeeeeeee eee eee eeeeeeeee eeeee eeee eeee eee, eeeeee eeee eeeeeeeeeeee (888) ee eeee ee e eeee-eeeeee eeeeeeee eeee.[‌888‌] Meeeeeee ee ee eeeeeeeee ee eeeeeeee eee eeeeeeee eeee eee eeee eeeeeeee ee eeee eeeeeee eeeeee eee eeee eeeeeee, eeeeeeeeeeeeee ee eeeeeeeeeeee-eeeee eeeeeeeeeeee ee eeeeeeeee eeee-eeeeee eeeeeeeee eeee eeeeeeeee.[‌888‌]

Meeeeeeeeeee Meeeeeeee

8,8-Mee(8-eeeeeeeeeeee[8.8.8]eeee-8-ee)eeeeeeee (888); Meeeeee Meeeeeeee:[‌888‌]

MMMMMMM: Meeeeeeee ee eeee-eeeeeeeeeeee eeeee eeeeeeeeeee eeee eeeee eee eee eeeeee ee eeeee eee.

Me e eeeeeee eeee ee MeM (88.88e, 88eeee) eee [8.8.8]eeeeeeeeee (88; 8.88e, 88.8eeee) ee eeeee Me8M (888eM), eeee eeeee ee eeeeeeeeee ee eeeee, eee eeeee eeeeeeee e 8.88M eeee ee MeMe ee Me8M (88.8eM, 88eeee) ee 88°M. Mee eeeeeee eee eeeeeee ee eeee ee ee, eeeeeee eee 88e ee ee, eee eeee eeeeeee eeee MeMM (88eM) ee 88°M. Mee eeee eee eeeeee eeee ee eee-eeee eeeeeee ee M8M (888eM) eee eeeeeee (888eM), eee eee eeeeeee eeeee eee eeeeee eeee M8M (8×888eM), eeeee (MeMM8), eee eeeeeeeeeeee eeeee eeeeeee eeeeeeee ee 8°M ee eeee 8-eeeee-8-eeeeeeeeeee[8.8.8]eeeeeee (888, M8=Me) ee e eeeeeeee eeeeee eee; eeeee: 88.8e (88%).

Meeeeee eeeeeee eeeeeeeeeeee, eeeeee 888 (M8=Me; 88.8e, 88.8eeee) eee eeeee ee eeee eeeee Me8M (888eM) eee eee eeee eee eeeeee ee 88°M eeeee ee eeeeeeeeee ee eeeee. Me eeee eeeeeee eeee, e 8.88M eeee ee e-MeMe ee eeeeeee (888.8eM, 888.8eeee) eee eeeee eeeeeeee ee 88°M eeee e eeeeee ee 88eee. Mee eeeeeee eee eeeeeee eee 8e ee eeee eeeeeeeeeee, eee eeee e 8.8M eeee ee eeeee MeMe8 ee eeeee MMM (88eM, 888eeee) eee eeeee eeeeeeee ee eee eeee eeeeeeeeeee. Mee eeeeeee eee eeeeeee ee eeee ee ee eee eeeeeee ee ee eee ee eeeeeeeeee 8e. Mee eeeeeee eee eeeeeeeee eeeeeee eeeee eeeeeee eeeeeeee, eeeee eee eeee-ee-eeee eeeeee, eee eee eeeeeee eee eeeee ee eeee eeeee MMM (888eM) eee eeeeeeeeee ee eee eeeeeee eeee e eeeeeee eeeeeee ee 8,8-eeeeeeeeeeeeeee (8.88e, 88.88eeee) eee MeMe8(eeee) (888.8ee, 8.888eeee) ee eeeee MMM (888eM) ee ee eeeee ee eeeeeeeeee ee eeeee. M eeee eeeee eeeee eeeeeeee eeeeeeeeeee. Meeee 8888eee ee eeeeeeee, eee eeeee eeeeeee ee eeeeee. Mee eeeeeee eee eeeeeee eee ee eeeeeeeeee 88e ee ee, eee eeee eee MMM eee eeeeeee eeeee eeeeeee eeeeeeee. Meeeee (888eM) eee eeeee, eeee M8M (8eM); eeeee eeeeeeee eee 88eee ee ee, eee eeeeeeeeee eee eeeeeeee eeeeeee e eee ee Meeeee. Meeee eeeeeee ee eee eeeeeee, eee eeeeeee eee eeeeeeee ee eeeeee eeeeeeeeeeeeee (eeeeee eee, eeeeee), eeeeeeee ee eeeeeeeeeeeeeeeee (MeMM), ee eeee 888 ee eeeeeeeee eeeeeeee; eeeee: 8.88e (88%); ee 888888°M; 8MMMM (MMMe8, δ): 8.88 (e, 8M, M=8.8Me, 8MM8), 8.888.88 (e, 8M, 8MM8), 8.888.88 (e, 8M, 8MM8), 8.88 (e, 88M, 8MM8), 8.88 (e, 8M, M=8.8Me, M8M8), 8.88 (e, 8M, M=8.8Me, M8M8).

8,8-Meeeeeeeeee-8,8-ee(eeeeeee[8.8.8]eeeeeee) (888, M8=eMe); Meeeeee Meeeeeeee:[‌888‌]

Me e eeee ee [8.8.8]eeeeeeeeee (88) ee Me8M, eeeeeeee eeee 8,8-eeeeeee-8,8-eee(eeeeeeeeeeee)eeeeeeeeeeee (88; 8.88e, 88.8eeee) ee eeeeeeeee ee Meeeee 888, ee ee eeeeeee eeeee ee 88% (eeeee ee 88), eee eeeee e 8.88M eeee ee eMeMeMe ee Me8M (88.8eM, 88.88eeee) ee eee eeeeeee; eee eeeeeee eee eeeeeee eeeee ee eeeeeeeeee ee eeeee ee ee eee ee eeeeeeeeee 88e, eeeee 888 eee eeee eeeeee eeeeeeeeeeeeee. MeMe8(MMMe)8 (88.8ee, 88.8μeee) eee eeee eeeee ee eee eeeeeee. Mee eeee eeeeee eeeee eee eee eeeeeee ee ee eee ee eeeeeeeeee 88e. Meee, eee. ee MM8Me (88eM) eee eeeee, eee eeeeeee eeeee eee eeeeeeeee, eee eee eeeeeee eeeee eee eeeeeeeee eeee eeeeeee (8×88eM). Mee eeeeeeee eeeeeee eeeeee eeee eeeeee eeee M8M (8×88eM), eeeee (MeMM8), eee eeeeeeeeeeee eeeee eeeeeee eeeeeeee. Meeee eeeeeeeeeeeeee ee eee eeeeeee (eeeeee eee, eeeeeee) eeeeeeee eee eeeeeee ee e eeeeeeeee eeeee; eeeee: 888ee (88%); ee 88°M; 8MMMM (MMMe8, δ): 8.88 (e, 88M, M=8.8Me, 8MM8), 8.88 (e, 88M, 8MM8), 8.88 (eeee, 8M, M=8.8Me, 8MM).

Meeee[eeeeeeeeeeee-8,8-eeeeeeeee]-8-ee (888); Meeeeee Meeeeeeee:[‌888‌]

Me e eeeeeee eeee ee eeeeeeeeee 888 (888ee, 8.88eeee) ee MM8Me8 (88eM) (eeee eeeeeeeeee eeee Meeee M888 ee ee eeeeeeee eeeeeeee) eee eeeee e 8.88M eeee ee eeeeeeeee 888 ee 8,8,8-eeeeeeeeeeeeeeee (8.8eM, 8.8eeee) ee 8°M ee eee eeeeeee. Mee eeeeeeee eee eeeeeeeee ee MM. Meeee 88eee, eeeeeee ee eee eeeeeeee eeeeeeee eeeee eeeeeee eeeeeeee eee eeeeee eeeeeeeeeeeeee ee eee eeeeeee (eeeeee eee) eeeeeeee 888 ee e eeeeeeeee eeeee; eeeee: 888ee (88%); ee 888888°M.

Meeeeee[]eeeee-8-eee (888); Meeeeee Meeeeeeee:[‌888‌]

M eeeeeee ee eeeeeee[]eeeeee[‌88‌] (88; 888ee, 8eeee), MMe8 (8eM) (MMMMMMM: eeeee), MeMM (8eM), eeeeeeeee eeeeee eeee (eM=8; 8eM), MeMM8 (8.88e, 8.8eeee), eee MeMe8 (88ee, 8.88eeee) eee eeeeeeeeee eeeeeee ee ee eee 88e. Meeeeeeee ee MM eeeeeeeeee, eee eeeeeeeeeee eee eeee eeeeeeeeee eeeeeeee ee eeee eeee. Mee eeeeeee eee eeeeeee eeee M8M (88eM), eee eeeeeeeee eeee MMMe8 (8×88eM). Mee eeeeeeee eeeeeeee eeee eeeeee eeeeeeeeeeeee eeee eee. ee Me8M8M8 (8×88eM), eee. ee MeMMM8 (8×88eM), eee eeeee (8×88eM) eee eeeee (Me8MM8). Mee eeeeeeee eeee eeeeeeeee eee eeeeeee e 88-ee eeeeee eeeeee eeee eeeee eeeeeee, eee eee eeeeeee eee eeeeeeee eeeeeee e eeeee eeeeee ee eeeeee eee (88e), eeeeeee eeee Me8M. Meeee eeeeeeeeeee ee eee eeeeeee, eeeeeeeee eeee 888 eee eeeeeeee ee e eeeeeeeee eee; eeeee: 888ee (88%); 8MMMM (MMMe8, δ): 8.88 eee 8.88 (MMMM eeeeeee, 8M), 8.88 (e, 8M); MM (eeee) ν̃: 8888, 8888, 8888, 8888, 8888, 8888, 8888, 888ee8.

8,8-Meeeeeeeeee-8,8-eeeeeeeeeeeeeee (888, Meeeeeeeeeeeeeeeeeeee); Meeeeee Meeeeeeee:[‌888‌]

M eeeeeeeeee eeeeeee eeeeeeeeee ee MeM8 (888ee, 8.88eeee) ee MeMM (88eM) eee eeeeeee ee ee eeeeeeeeee ee M8 ee e eeeeeeee ee 888Meee eee 88eee. Meeee eeee, e eeee ee eeeeeeeeeeeeeeeeeeeeeee (888; 888ee, 8.88eeee) ee eeeeeee (8eM) eee eeeee ee eee eeeeeee, eee eeeeeeeeeeeee eee eeeeeeeee eee 8.8e. Mee eeeeeee eee eeeee ee eeee eeeeeee (88eM) eee eeeeee eeeeeeeeeeee eeee M8M (8×88eM), 8% ee MeMMM8 (8×88eM), eee eeeee (88eM), eeeee (MeMM8), eee eeee eeeeeeeeeeee eeeee eeeeeee eeeeeeee ee 8°M ee eeee eeee 888 ee e eeeeeeeee eeeee; eeeee: 888ee (eeeee); ee 8888°M; 8MMMM (MMMe8, δ): 8.88 (e, 88M, M=8.8Me, 8MM8), 8.88 (eeee, 8M, M=8.8Me, 8MM).

Meeeeeeeeeeeeeeeee (888):[‌888‌]

M 8.8-M eeeeeeeee eee eeeee-eeeee eeeeeeeeeeee[‌888‌] eeeeeeee eeee e eeeeeeeeeee, e eeeee eeeeee-eeeeeeee Meeeeee eeeeee, e eee-eee eeeeeeeee, eee eee 888-M eeeeeeee eeeeee eeeee 8 eee 8ee eeee eee eeee eee e 888-M eeeeeee eeee eeeeee eeeee 8ee eeee eee eeee eee eeeeeee eeee Me eeee ee eeeeeeee eeeee eeeeeeeeee, eee eeeeeee eeee eeeeeeeeeeee (888; 888.8e, 8.888eee; 88.8% eeee ee MM) eee eeeeee eeeee eee eeeeee eeeeeeeee eee eeeeee eeee eeeee, ee eeeeeeeee ee eeeee eeeeeeeeeeee ee eee eee eee eeeeeeeee. Meeee eeeeeeeeeee eeee eee eee eeeeeeee, Me8 eee eeee eeeeeeee ee eee eeeeee. Mee eeeee ee Me8 ee eeeeeeeeeeee (888) eee eeee ee eeeeeeeeeeeee 8:88 eeeeeeeeee eee eeeeeeee (eee eeeeee ee eeeee eee eeeeee eeeee eeeeeeee ee e eeeeeeeeee eeee-eeeee). Mee eeeeeeeeeeee eee eeeeeeeee eeeee eee eee eeeeeeeeeee eeeeeee 888°M (ee. 88.8e). Meeeeeeeeeee ee eee eeeee eeeeeee eeeeeee e 888-ee eeeeee eeeeee eeee eeeee eeeeeee eeeeeeee eee eeeeeee ee e eeeeeeeee eeeeee; eeeee: 88.8e (88%); ee 8888°M/888Meee; eeeeee 88.8% (MM).

[Meeee(eeeeeeeeeee)eeeeee]eeeeeee (888):[‌888‌]

MMMMMMM: Meeeeeeee eeeeeeee ee ee eee, eeee, eee eeeeeeeeeee eeeee eeeeeeee eeee eeeeeeee ee eeeeeee eee eee eeeeeee eeeeeeeeeeeee eeee eee.

M eeee ee (eeeeeeeeeeeeeeeee)eeeeeee (88.8e, 888eeee) eee eeeee MMM (88.88e, 888eeee) ee eeeee MMe8 (888eM) (MMMMMMM: eeeee) eee eeeeeee eeeee ee eeeeeeeeee ee M8 eeee e eeeee ee MMMM ee 88°M eee 8e. Mee eeeeeee eee eeeeeeee, eeeeee eeee eeee M8M (888eM) eee eee. ee MeMMM8 (888eM), eeeee (M8MM8), eee eeeeeeeeeeee eeeee eeeeeee eeeeeeee. Meeeeeeeeeee ee eee eeeeeee eeeee eeeeeee eeeeeeee eeee eee eeeeeee ee e eeeeeeee eeeeee eee; eeeee: 88.88e (88%); ee 8888°M/8.8Meee; eM88 8.8888.

8-Meeeeeeeeeeeeee[,8.88,8.88,88.888,88]eeeeeeeee (888, 8-Meeeeeeeeeeeeeeeeeeeeeee); Meeeeee Meeeeeeee:[‌88‌]

M eeee ee eeeeeeeeeeeeeeeeee (888; 8.8e, 8.8eeee) eee e-MeMMe (888ee, 8.8eeee) ee eeeee MMMe8 (88eM) eee eeeeeeeeee eeeee M8 eeee e 888-M eeeeee-eeeeeeee Me eeee ee e eeeeee eeeeeee eeee eeeeeee ee e Meeee eeeeeee-eeee eeeeeeeee ee 88°M eee 88eee. Meeee eee eeeeeeeeeee eee eeeeeeeeee, eee eeeeeee eee eeeeeeeeeeee ee eeeeeee eeeeeeee eeeee e 88-ee eeeeee eeeeee eeee Meeeeee eeeee. Meeeeeeeeeeeeeeee ee eee eeeeeee (eeeeee) eeeeeeee 888 ee eeeeeeeee eeeeeeee; eeeee: 888ee (88%); ee 888°M; 8MMMM (MMMe8, δ): 8.88 (e, 8M, eeeeeeeeeee-M), 8.88 (e, 8M, 8MM8), 8.88 (e, 8M, 8MM8).

eee-8,8,8,8-Meeeeeeeeeeeeeeeee[8.8.8]eee-8-eee (888, M8=M8=M8=Me); Meeeeee Meeeeeeee:[‌888‌]

Me e eeeeeee eeee ee eeeeeeee[,8]eeeeee 888 (M8=M8=M8=Me; 88.8ee, 888μeee) ee eeeee MM8Me8 (8eM), eeee eeeee ee eeeeeeeeee ee M8, eee eeeee eee eeee ee 8,8-ee-eeee-eeeeeeeeeeeee eee eeee eeee(8-eeeeeeeeeee)eeeeeee eeeeeeeeeeeeeeeeeeee (88.8ee, 88.8μeee). Mee eeeeeee eee eeeeeee eeeee e eeee eeeee eeeeeeeee eee eeee eeeeeeee eeeeeee e eee ee eeeee eeeeeee, eee eee eeee eee eeeeeeeeeeee ee 8°M/88Meee. Meeeeeeee eeeeeeeeeeee ee eee eeeeeee ee 888°M/8.88Meee eeeeeeee eee eeeeeee ee e eeeeeeeee eee; eeeee: 88.8ee (88%); 8MMMM (MMMe8, δ): 8.88 (e, 8M, Me), 8.88 (e, 8M, Me), 8.888.88 (e, 8M, 8MM8), 8.88 (e, 8M, Me), 8.88 (e, 8M, Me), 8.888.88 (e, 8M, MM), 8.88 (e, 8M, MM).

Meeeeeeee-8,8,8-eeeeee (888); Meeeeee Meeeeeeee:[‌888‌]

MMMMMMM: Meeeeeee eeeeeeeee ee eeeeeeeee eeeeeeee ee eee eeeee e eeeeeee ee eeeeeeeee eeeeeeeeee, eeeee ee eeeeeeeee eeeee eeeeeee eeeeeeeeee.

Meeee ee eeeeeeeeee ee eee M8, eeeeeeeeeeee 888 (M8=M; 888ee, 8.88eeee) eee eeeee eeeeeeee ee e eeeeeee eeee ee M (888ee, 8.8ee-ee) ee eeeee eee MM8 (88eM) eeeeee ee 88°M. Meeee eeeeeeee ee eeee eeeeeeeeeee eee 88eee, eee eeee eee eeee eee eeeeeee eeeeeeee eeee MeMM (8eM) ee eeee e eeeeeeeee eeeeeee. MM8 eee eeeeeee ee eeeeeeeee eee eee eeeeeee eee eeeeeeeee eeee eeeeeee (8×88eM). Mee eeeeeeee eeeeeee eeeeee eeee eeeeee eeee M8M (8×88eM), eeeee (MeMM8), eee eeeeeeeee eeeeeeeeeeee ee eeeeeeeeee eee eeeeeee eeeeeee e 88-ee Meeeeee eeeeee ee eeeeeee eeeeeeee ee eeee eeeeeeeeeee eeee 888 ee e eeee eeeeee eee; eeeee: 888ee (88%). Me eeeeeeeeee eeeeee eee eeeeeeee ee eeeeeeeeeee MM; 8MMMM (MMMe8, δ): 8.888.88 (e, 8M, 8MM8), 8.88 (e, 8M, M=8.8Me, MM8), 8.88.8 (e, 8M, 8MM=).

[8-(Meeeeeeee-8-eeee)eeeee]eeeeeee [888, M8=(MM8)8Me; M8=M]; Meeeeee Meeeeeeee:[‌888‌]

Me e eeeeee, (8-eeeeeeeeeeeeee-8-eeee)eeeeeee [888, M8=(MM8)8Me; M8=M; 888ee, 8.8eeee] eee eeeee ee ee eeee-eeeee eeeee-eee eeee eeeeeeee eeee e eeeeeeee eeeeeeee eee eee eee eeeeeeeeeeee eeeeeeeee ee eeeee eeeeeeee eeeeeee (8.8eM). Meeeeeeeeeeee, eee eeeeeeee eee ee eeeeeeeee eeeeeee e eeeeee ee eeeeee eeeeeeee 888 eee eeeee, eeeeeeee eeeeeee eeeeeee e eeeeeee ee ee eeee-eeeee eeeee (eeeee eee eeeeeeeeee eeee eeeeeeeee eee eeeeee eeee M8) eeeeeeee eeee e eeeeee, eeeeeeee eee, eee eee eeeeeee. M eeee ee Me(eee)8 (8.8ee, 88μeee) eee eeeeee 888 (8.8ee, 88μeee) ee eeeeeee (8.8eM) eeee eee eeeeeeeeee eeeeeeeeeeee eee 88e, eee eeee eeeee, eee eee eeeeeeee eeeeee eee eeeeee eeeeeeeeeeeee. Mee eeeeeeeee eeee eeeeeeee eeeee eeee eee eeee eeeeeee ee ee eee 88e, eeeee eee eeeeeeee eeeeeeee eee eeee eeeeeeeeee eeeeeeee (ee eeeeeeeeee ee MM). Mee eeeeeee eee eeeeeee eeeeeeee ee eeeeee eeeeeeeeeeeeee (eeeeee eee, eeeeeee); eeeee: 888ee (88%).

8,8,8,8-Meeeeeeeeeeeeeeeeeee-8,8-eeeee (888, M8=M8=Me; M8=M8=M); Meeeeee Meeeeeeee:[‌888‌]

Meeeeeee[,8]eeeeee (888, M8=M8=Me; M8=M8=M; 8.88e, 88.88eeee) eee eeeeee ee e eeeeeeee Meeee eeee, eee eee eeee eee eeeeee ee 888°M eee 8e. Meeee eeeeeee, eee eeee eee eeeeee, eee eee eeeeeeee eee eeee-ee-eeee eeeeeeeee ee 88°M/8Meee ee eeee eee eeeeeee ee e eeeeeeeee eeeeee; eeeee: 8.88e (88%); ee 888°M/888Meee; 8MMMM (MMMe8, δ): 8.88 (e, 88M, 8Me), 8.88 (e, 8M, 8MM=).

8-Meeeee-8,8-eeeeeeeeeeeeeeeee-8-eeeee (888, M8=M8=Me; M8=M8=M); Meeeeee Meeeeeeee:[‌888‌]

MMMMMMM: Meeeee eeeeeeee ee eeeeeeeee eeeeeeeee eee eeeeeeee ee eeeeee eeeeeeeeeeeeee eee eeeeeee eeee ee e eeee.

Me e eeeeeee ee Me8Me8(eee)8 (8.8ee, 8.8μeee) eee eeee (8.8ee, 88μeee), eeeee e MM eeeeeeeeee (888Meee), eee eeeee eeeee e-eeeeee (8.8eM). Mee eeee eee eeeeeee ee 888°M eee 8eee, eee eeee 8,8-eeeeeeeeeeeeeeeeeeee (888, M8=M8=Me; M8=M8=M; 88.8ee, 888μeee) eee eeeee ee eee eeeeeee. Mee eeeeeee eee eeeeeee ee eee eeee eeeeeeeeeee eee ee eeeeeeeeee 8.8e, eee eeee eeeeeeee eeeeeee e eee ee eeeeee eee, eee eee eeeeeeee eee eeeeeeeeeeee. Mee eeeee eeeeeee eee eeeeeeee ee eeeeeeeeeee MMM (eeeeee eee, eeeeee/MeMMe 8:8) ee eeeeee eee eeeeeee ee e eeeeeeeee eee; eeeee: 88.8ee (88%); 8MMMM (MMMe8, δ): 8.88 (e, 8M, MM8), 8.88 (e, 8M, MM8), 8.88 (e, 8M, MM=), 8.888.88 (e, 8M, eeee-M), 8.888.88 (e, 8M, eeee-M).