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1.2.7 Radical-Based Palladium-Catalyzed Bond Constructions

DOI: 10.1055/sos-SD-101-00568

Li, Y.; Xie, W.; Jiang, X.Science of Synthesis Knowledge Updates, (201621.

General Introduction

During the evolution of organic chemistry, palladium catalysts have played an important and irreplaceable role in studies on carbon–carbon[‌1‌‌7‌] and carbon–heteroatom[‌8‌‌10‌] bond formation. Beyond the methodological studies, palladium-catalyzed reactions have also been widely applied in the preparation of natural products,[‌11‌] pharmaceuticals, agrochemicals, and materials, even on large scale.[‌12‌] Palladium(0) and palladium(II) species are frequently used as the catalysts and considered as active intermediates, participating in oxidative addition and reductive elimination steps in two-electron-transfer processes.[‌1‌‌15‌] Throughout the development of palladium chemistry, an increasing number of single-electron-transfer procedures have been proposed and carefully studied, which mainly involve palladium(I)[‌16‌] and palladium(III)[‌17‌] species. The focus of this chapter is on radical-based palladium-catalyzed bond constructions in organic synthesis.