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Please login to access the full content or check if you have access via β-Silyl Carbonyl Compounds (Update 2013)

DOI: 10.1055/sos-SD-104-00164

Nahra, F.; Riant, O.Science of Synthesis Knowledge Updates, (20132197.

General Introduction

β-Silyl carbonyl or carboxy compounds are attractive synthetic intermediates (Scheme 1).[‌1‌‌9‌] The position of the silyl group far from the carbonyl group allows for numerous transformations on the latter, and, with the well-known resistance of the silyl group to a wide range of conditions,[‌10‌] more complex molecules can be constructed from this type of intermediate. If the silyl group is installed enantioselectively on a saturated carbon, it can influence the adjacent addition of other groups.[‌11‌,‌12‌] The silyl group can be retained through several synthetic steps, only to be converted later into another functional group.

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