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4.4.7.2.7.3 Transition-Metal-Catalyzed Propargylic Substitution

DOI: 10.1055/sos-SD-104-00395

Delvos, L. B.; Oestreich, M.Science of Synthesis Knowledge Updates, (20171149.

SN2′-type substitution reactions with transition-metal-based silicon nucleophiles emerging from Si—B bond transmetalation are not limited to allylic electrophiles. Propargylic substrates are silylated with comparable efficiency and site selectivity to provide di-, tri-, and tetrasubstituted allenes.[‌121‌,‌122‌]

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References


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