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7.1.9.11.1.1 Carboalumination of Alkenes and Alkynes

DOI: 10.1055/sos-SD-107-00059

Oishi, M.; Takikawa, H.Science of Synthesis Knowledge Updates, (2010493.

As described in Section 7.1.9.6.1, the successful carboalumination of alkenes with tri­methylaluminum as well as ethyl or higher alkyl congeners has been realized with the assistance of bulky chiral zirconocene catalyst 1.[‌1‌] Both enantiomers of 1 can be obtained from the appropriate enantiomers of menthol with relative ease.

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Meeeee 8 Meeee Meeeeeeee eee eee Meeeeeeee ee Meeeee-Meeeeeee Meeeeeee[‌8‌‌8‌]

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Meeeee 8 Meeeeeeee ee Meeeeeeeeeeee eee Meeeeeeee-Meeeeeeee Meeeeeeeee Meeeeeeeeeeeeeee[‌88‌]

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Meeeee 8 Mee-Mee Meeeeeeeee Meeeeeeeeeeeeeeee–Meeeeeeee-Meeeeeeee Meeee-Meeeeeee Meeeee Meeeeee[‌88‌]

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Meeeee 8 Meeeeeeeeeeeee Meeeeeeeeeeeeeeee ee Meeeeeee Meeeeee[‌88‌]

Meeeeeeeeee 8

M8 Meeeeeeeeeee M Meeee (8/8) Meeee (%) Mee
(MM8)8MMMMM M8M M >88:8 88 [‌88‌]
(MM8)8MMMMM MMM Me >88:8 88 [‌88‌]
>88:8 88e [‌88‌]
Me 88.8:8.8 88e [‌88‌]

e MeMM (88 eee%) eee eeee ee eeeeeeee.

e Me(8) (8 eee%) eee eeee ee eeeeeeee.

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Meeeee 8 Meeeeeeee ee Meeeeeee M88 eee Meeeeeeee-Meeeeeeee Meeeeeeeeeeeeeee/Meeeeeee Meeee Meeeeeeeeeeeeeeeeee ee 8-Meeeeeeeeeee-8-ee[‌88‌]

Meeeeeeeeee 8

Meeeeeee Meeee (8/8) Meeee (%) Mee
MMMM >88:8 88 [‌88‌]
eMeMM >88:8 88 [‌88‌]

Meeeeeeeeeee Meeeeeeee

(8M)-8-Meeeeeeee-8-eee (8); Meeeeee Meeeeeeee:[‌88‌]

MMMMMMM: Meee eeeeeeeeeeeeeeeee ee eeeeee eeeeeeeeee.

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References