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Please login to access the full content or check if you have access via Variation 3: From Nb-Aryl Benzophenone Hydrazones and Ketones

DOI: 10.1055/sos-SD-110-00001

Joule, J. A.Science of Synthesis Knowledge Updates, (2010235.

Nb-Aryl benzophenone hydrazones 115 can be obtained via the palladium-catalyzed coupling of aryl bromides with benzophenone hydrazone using palladium(II) acetate with Xantphos. The Fischer synthesis is achieved by a one-pot hydrolysis of the benzophenone Nb-arylhydrazone in the presence of a ketone, indole formation then following.[‌173‌] Scheme 42 shows a selection of examples of one-pot formation of indoles 116 from Nb-aryl benzophenone hydrazones 115.

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